Protein Info for DZA65_RS18660 in Dickeya dianthicola ME23

Annotation: transporter substrate-binding domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00497: SBP_bac_3
  • amino acids 32 to 253 (222 residues), 139.3 bits, E=7e-45

Best Hits

Swiss-Prot: 50% identical to PHEC_PSEAE: Cyclohexadienyl dehydratase (pheC) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K02030, polar amino acid transport system substrate-binding protein (inferred from 94% identity to ddc:Dd586_3436)

MetaCyc: 50% identical to arogenate dehydratase (Pseudomonas aeruginosa PAO1)
Arogenate dehydratase. [EC: 4.2.1.91]; Prephenate dehydratase. [EC: 4.2.1.91, 4.2.1.51]

Predicted SEED Role

"Cyclohexadienyl dehydratase (EC 4.2.1.51)(EC 4.2.1.91)" in subsystem Phenylalanine and Tyrosine Branches from Chorismate (EC 4.2.1.51, EC 4.2.1.91)

MetaCyc Pathways

• superpathway of chorismate metabolism (54/59 steps found)
• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• L-phenylalanine biosynthesis I (3/3 steps found)
• L-phenylalanine biosynthesis III (cytosolic, plants) (2/2 steps found)
• L-phenylalanine biosynthesis II (3/4 steps found)
• superpathway of L-phenylalanine and L-tyrosine biosynthesis (3/5 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.51

Use Curated BLAST to search for 4.2.1.51 or 4.2.1.91

Sequence Analysis Tools

See A0A3A4DVJ1 at UniProt or InterPro

Protein Sequence (255 amino acids)

>DZA65_RS18660 transporter substrate-binding domain-containing protein (Dickeya dianthicola ME23)
MKKRFSLMLLLGLAGGASAASHLDQVQAQGVLKVCTTGDYKPYTSLRADGDYEGIDIAMA
QSLANSLGVKVEWVKTSWKTLMPDFQSGQCDIGMGGISVTLERQKKAFFSSTLDVDGKIP
LVRCDDKDQYQTVAQINQPSVRVIEPAGGTNEAFVHAHLPNARLALHDNVTIFQQLVDKQ
ADVMITDASEALYQQKRYPQLCAVNPSSPMQYGEKAYMLPRDDLSWKLYVDQWLHLSKST
GEYRRIMSEWLGKVE