Protein Info for DZA65_RS17885 in Dickeya dianthicola ME23

Annotation: glycine betaine/L-proline ABC transporter substrate-binding protein ProX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 332 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF04069: OpuAC" amino acids 31 to 313 (283 residues), 175.3 bits, see alignment E=9.6e-56

Best Hits

Swiss-Prot: 93% identical to OUSX_DICD3: Glycine betaine-binding periplasmic protein OusX (ousX) from Dickeya dadantii (strain 3937)

KEGG orthology group: K02002, glycine betaine/proline transport system substrate-binding protein (inferred from 93% identity to ddd:Dda3937_00899)

MetaCyc: 76% identical to glycine betaine ABC transporter periplasmic binding protein ProX (Escherichia coli K-12 substr. MG1655)
RXN-8638 [EC: 7.6.2.9]; 7.4.2.- [EC: 7.6.2.9]

Predicted SEED Role

"L-proline glycine betaine binding ABC transporter protein ProX (TC 3.A.1.12.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (TC 3.A.1.12.1)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CUC9 at UniProt or InterPro

Protein Sequence (332 amino acids)

>DZA65_RS17885 glycine betaine/L-proline ABC transporter substrate-binding protein ProX (Dickeya dianthicola ME23)
MRNISMATLALTTVLSTGLFAADDLPGKGITVKPVQSTLSEETFQTLLVSKALEKLGYTV
DKPSEVDYNVGYTSVANGDATFTAVNWQPLHDDMYQAAGGDTTFYRKGVYVSGAAQGYLI
DKKTAERYHITRLDQLKDPQLAKLFDTNGDGKADLTGCNPGWGCEGVINHQLQAYGLGNT
VNHNQGNYAALIADTIARYKQGKPILYFTWTPYWVSDVLVPGHDVVWLQVPFSSLPGKQK
GTDTKLPNGANYGFPVSSMHIVANKDWAEKNPAAATLFATMKLPLADINAQNLRMHQGEA
SQEAIERHVNGWIKAHQAQFDGWINAARAAAK