Protein Info for DZA65_RS17520 in Dickeya dianthicola ME23

Annotation: HTH-type transcriptional regulator EutR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 347 PF12833: HTH_18" amino acids 261 to 342 (82 residues), 66.7 bits, see alignment E=1.8e-22

Best Hits

Swiss-Prot: 59% identical to EUTR_ECOLI: HTH-type transcriptional regulator eutR (eutR) from Escherichia coli (strain K12)

KEGG orthology group: K04033, AraC family transcriptional regulator, ethanolamine operon transcriptional activator (inferred from 96% identity to ddd:Dda3937_03174)

Predicted SEED Role

"Ethanolamine operon regulatory protein" in subsystem Ethanolamine utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CV36 at UniProt or InterPro

Protein Sequence (347 amino acids)

>DZA65_RS17520 HTH-type transcriptional regulator EutR (Dickeya dianthicola ME23)
MKHNPVNLHHLDAVRRLPATTAASPGDNVHQRQTEDVYAQSRTITAWQQIYDQVSPGHFN
GELQEILLDGIQLCHEYTSLALRQSCMVWPDSFWFGIPARHVGTGFIGSHPISNNAIAVS
PGGKEFELNTPDDYAILGVVVSRDELLQYTDVLEQPEHLTRLLAQSATLLVEPRRREIFW
SFVREALWYGGHEPQRLRHSNAVKVLKHNLLTTVISFLESAQPAVAGTAHTDKRIGYRSL
IGHAREYVLSQQSEPVTVLDLCRRLHVSRRTLQNAFCDVMGCGPNAWLKMIRLNAVRREL
VSPYSRHRTVQDAAMQWGFWHLSQFACDYQRLFDEKPSVTLKARLAG