Protein Info for DZA65_RS16700 in Dickeya dianthicola ME23

Annotation: Fe-S protein assembly chaperone HscA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 616 PF00012: HSP70" amino acids 21 to 600 (580 residues), 660.8 bits, see alignment E=1.7e-202 TIGR01991: Fe-S protein assembly chaperone HscA" amino acids 21 to 615 (595 residues), 907.3 bits, see alignment E=2.3e-277 PF06723: MreB_Mbl" amino acids 128 to 373 (246 residues), 49 bits, see alignment E=4.2e-17

Best Hits

Swiss-Prot: 83% identical to HSCA_PECCP: Chaperone protein HscA (hscA) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)

KEGG orthology group: K04044, molecular chaperone HscA (inferred from 96% identity to ddd:Dda3937_03693)

MetaCyc: 81% identical to iron-sulfur cluster biosynthesis chaperone HscA (Escherichia coli K-12 substr. MG1655)
3.6.4.-

Predicted SEED Role

"Chaperone protein HscA" in subsystem Protein chaperones

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CCN9 at UniProt or InterPro

Protein Sequence (616 amino acids)

>DZA65_RS16700 Fe-S protein assembly chaperone HscA (Dickeya dianthicola ME23)
MALLQISEPGLSAAPHQHRLAVGIDLGTTHSLVATVRSGETQTLPDHDGRYLLPSVVHYH
ADGLTVGWDARRQAALDPVNTVSSVKRLMGRSLADIRQRYPHLPYQFEASENGLPVLQTA
AGPRNPIQVSADILTALTRRAEEALNGLPDGVVITVPAYFDDAQRQGTKDAARLAGLHVL
RLLNEPTAAAVAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLSTGGDSALGGDD
FDHLLVEWIRERAGITTRDDHQLQQVLLNTAVQTKIALSDAQTVPVSVAGWQGDITREQF
NALIAPLVKRTLLSCRRTLKDADVDADEVKEVVMVGGSTRVPMVREQVGEFFGRMPLTSI
DPDKVVAIGAAIQADILVGNKPDSDMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARA
QEFTTFKDGQTAMMIHVLQGERELVQDCRSLGRFTLRGIPPMPAGGAHIRVTFQVDADGL
LSVTAMEKSTGVEASIQVKPSYGLSDDEIAAMITDSMQNAQSDIGVRRLAEQRVEAARVL
ESLASALATDAALLNDEERAAIDAARLQLQQAAQETDASAIEAAIKTVDQQTQEFAARRM
DESIRRALAGHSVDEV