Protein Info for DZA65_RS16170 in Dickeya dianthicola ME23

Annotation: multidrug efflux RND transporter permease subunit MdtC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1029 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 336 to 353 (18 residues), see Phobius details amino acids 360 to 384 (25 residues), see Phobius details amino acids 390 to 410 (21 residues), see Phobius details amino acids 431 to 451 (21 residues), see Phobius details amino acids 463 to 489 (27 residues), see Phobius details amino acids 528 to 545 (18 residues), see Phobius details amino acids 853 to 871 (19 residues), see Phobius details amino acids 878 to 898 (21 residues), see Phobius details amino acids 904 to 930 (27 residues), see Phobius details amino acids 951 to 970 (20 residues), see Phobius details amino acids 982 to 1008 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1008 (1005 residues), 1176.9 bits, see alignment E=0 PF03176: MMPL" amino acids 238 to 493 (256 residues), 38.3 bits, see alignment E=1.2e-13

Best Hits

Swiss-Prot: 78% identical to MDTC_ECO57: Multidrug resistance protein MdtC (mdtC) from Escherichia coli O157:H7

KEGG orthology group: K07789, RND superfamily, multidrug transport protein MdtC (inferred from 60% identity to bbr:BB4430)

MetaCyc: 77% identical to multidrug efflux pump RND permease subunit MdtC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-353; TRANS-RXN-92

Predicted SEED Role

"Multidrug transporter MdtC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CM58 at UniProt or InterPro

Protein Sequence (1029 amino acids)

>DZA65_RS16170 multidrug efflux RND transporter permease subunit MdtC (Dickeya dianthicola ME23)
MKFFALFIHRPVATTLLALAIALCGLIGYQLLPVSPLPQVDYPVISVTATLPGASPETMA
SSVATPLERSLGRIAGVNEMTSTSSLGNTRIILQFALDRDINGAARDVQAAINAAQSLLP
SSMPSRPYYRKVNPSDAPIMIITLTSDTYGPGQLYDYASTQIAQRVSQIDGVGDVTIGGS
SLPAVRVALNPQALFNQGVSLDAVRQSIAQSNVRQPLGSVDSGSTHYQIQTNDELKTADA
YRSLIVHYNNGAPVRLSDVATVKDSVQNVLNAGMTNAKPAVLVMIRRAPDANIISTVDAI
RASMPELQALLPASITLNVAQDRSPTIRASLRDVERSLTIAVSLVILVVFLFLRSGRATL
IPAIAVPVSLIGTFSAMYLCGFSLNNLSLMALTVATGFVVDDAIVVLENISRHIEAGMKP
LQASLQGVREVGFTVVSMSLSLIAVFIPLLFMDGLPGRLFREFSITLSVAILISLLVSIT
LTPMMCARLLRLHTPRSQPRTRGFNRLLLGLQQGYGRSLRWVLNHSRWVMMVLLCTIGLS
VWLYISIPKTFFPEQDTGRLMGFIQADQSISFQAMKRKLQDFMTIVRADPAVDNVTGFTG
GMRTNSGSMFISLKPLAQRDVSAQQVITRLRANLAKEPGANLYLMAVQDVRIGGREANGG
YQFSLLSDDLAVLRTWEPKIRDALSKLPQLADVSSDQQDKGAELMMVYDRDAMARLGINV
ASVNALLNNAFGQRQISTIYQPMNQYKVVMEVDSAYTQDPSSLDKMFVINNDGKPIPLSF
FARWQPANAPLAVNHQGLSAAATLSFNLPEGASLSDATTAIERTMTTLRVPSTVRGQFAG
TALAFQQSQHSQVVLIIAAILTVYIVLGILYENVAHPLTILSTLPSAGVGALLALELFGK
PFSLIALIGILLLIGIVKKNAIMMVDFALVAQREGKLPAREAIFRACMLRFRPIMMTTMA
ALFGALPLVLSNGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDSLQWRRRKRTD
ATAHTEPSA