Protein Info for DZA65_RS15940 in Dickeya dianthicola ME23

Annotation: imidazolonepropionase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 404 transmembrane" amino acids 273 to 292 (20 residues), see Phobius details TIGR01224: imidazolonepropionase" amino acids 25 to 401 (377 residues), 502.2 bits, see alignment E=4.1e-155 PF01979: Amidohydro_1" amino acids 61 to 378 (318 residues), 68.6 bits, see alignment E=5.8e-23 PF07969: Amidohydro_3" amino acids 206 to 379 (174 residues), 53.4 bits, see alignment E=3.2e-18

Best Hits

Swiss-Prot: 71% identical to HUTI_YERP3: Imidazolonepropionase (hutI) from Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 96% identity to ddd:Dda3937_01674)

MetaCyc: 65% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CTA6 at UniProt or InterPro

Protein Sequence (404 amino acids)

>DZA65_RS15940 imidazolonepropionase (Dickeya dianthicola ME23)
MTIACDSLWLGADLVTLRGGRYQVIEDGALAVSAGRILWLGARQALPAIVPSRVTDFGGG
IITPGFIDCHTHLVFGGDRSGEFEQRLNGVSYADIAAAGGGILATVNATRQADHDSLFAS
ALARLRPLLAEGVTTLEIKSGYGLDVGSELKMLRVIRELGRRQPVQIVSTCLAAHAIPPE
FSRQPEAWIDLVCRELLPAVVSEGLADAVDAFCEYLAFSPAQVERLFQAAQAHQLPVKLH
AEQLSSLHGSALAARFQALSADHLEHATEQDVAAMAAAGTVAVLLPGAYYLLRETQCPPV
DLFRRYGVPMAVASDCNPGTSPALSLRLMLNMACTLFRLTPEEALAGVTLHAARALGLEQ
SHGSLETGKVADFVHWPLARPAELVYWLGGQLPCTTIFRGEQRP