Protein Info for DZA65_RS15830 in Dickeya dianthicola ME23

Annotation: urocanate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 563 TIGR01228: urocanate hydratase" amino acids 14 to 561 (548 residues), 957.2 bits, see alignment E=1.3e-292 PF17391: Urocanase_N" amino acids 15 to 141 (127 residues), 205.5 bits, see alignment E=3.1e-65 PF01175: Urocanase" amino acids 144 to 356 (213 residues), 285.7 bits, see alignment E=3.3e-89 PF17392: Urocanase_C" amino acids 359 to 552 (194 residues), 310.8 bits, see alignment E=4.8e-97

Best Hits

Swiss-Prot: 86% identical to HUTU_TRIRP: Urocanate hydratase from Trifolium repens

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 96% identity to dze:Dd1591_1265)

MetaCyc: 74% identical to urocanase subunit (Pseudomonas putida)
Urocanate hydratase. [EC: 4.2.1.49]

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CXA2 at UniProt or InterPro

Protein Sequence (563 amino acids)

>DZA65_RS15830 urocanate hydratase (Dickeya dianthicola ME23)
MTTSSSTTSAVARVVRAPHGTELHCENWLIEAAYRMIQNNLDPDVAERPEDLVVYGGIGK
AARNWDCFDAILASLRQLKADETLLVQSGKPVGVFRTHADAPRVLIANSNLVPHWATWEH
FHELDKAGLMMYGQMTAGSWIYIGAQGIVQGTYETFAEAGRQHYHGDLSGKWILTAGLGG
MGGAQPLAGVLAGASVLAVECQESRIDFRLRTRYLDYKATRIDEALAMIAEAAAQKKAIS
VGLLGNAAEVLPELVKRANAGGMKPDIVTDQTSAHDPLNGYLPAGWSVARWQQERISNPE
AVMKAACASMAVHVQAMLDFCHMGVPTVDYGNNIRQRALDEGVRNAFDFPGFVPAYIRPL
FCEGKGPFRWVALSGDPQDIDKTDAKLKELFPDNHHLHRWLDMARERIAFQGLPSRICWL
GLGERHVAGLAFNEMVRNGELKAPIVIGRDHLDCGSVASPNRETEAMQDGSDAVSDWPLL
NALLNTAGGATWVSLHHGGGVGMGFSQHAGMVIVCDGSEQADARLARVLWNDPATGVMRH
ADAGYDAAKACAAAHQLNLPMVK