Protein Info for DZA65_RS15570 in Dickeya dianthicola ME23

Annotation: non-ribosomal peptide synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2200 2400 2600 2844 transmembrane" amino acids 525 to 543 (19 residues), see Phobius details amino acids 636 to 654 (19 residues), see Phobius details PF00668: Condensation" amino acids 2 to 445 (444 residues), 203.2 bits, see alignment E=1.7e-63 amino acids 1091 to 1503 (413 residues), 100.2 bits, see alignment E=2.9e-32 amino acids 1545 to 1976 (432 residues), 190.5 bits, see alignment E=1.2e-59 PF00501: AMP-binding" amino acids 469 to 830 (362 residues), 257.2 bits, see alignment E=5.9e-80 amino acids 1996 to 2356 (361 residues), 294.2 bits, see alignment E=3.3e-91 TIGR01733: amino acid adenylation domain" amino acids 490 to 903 (414 residues), 378.4 bits, see alignment E=3.9e-117 amino acids 2016 to 2429 (414 residues), 433 bits, see alignment E=1e-133 PF13193: AMP-binding_C" amino acids 887 to 965 (79 residues), 32.5 bits, see alignment (E = 3.5e-11) amino acids 2413 to 2496 (84 residues), 26.8 bits, see alignment (E = 2e-09) PF00550: PP-binding" amino acids 992 to 1053 (62 residues), 37.6 bits, see alignment (E = 5.3e-13) amino acids 2522 to 2585 (64 residues), 51.1 bits, see alignment (E = 3.2e-17) TIGR01720: non-ribosomal peptide synthase domain TIGR01720" amino acids 1375 to 1503 (129 residues), 78.3 bits, see alignment 6.1e-26 PF00975: Thioesterase" amino acids 2611 to 2827 (217 residues), 124.6 bits, see alignment 1.8e-39

Best Hits

Predicted SEED Role

"Enterobactin synthetase component F, serine activating enzyme (EC 2.7.7.-)" in subsystem Siderophore Enterobactin (EC 2.7.7.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.-

Use Curated BLAST to search for 2.7.7.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XZQ1 at UniProt or InterPro

Protein Sequence (2844 amino acids)

>DZA65_RS15570 non-ribosomal peptide synthetase (Dickeya dianthicola ME23)
MELPLVAAQPGIWMADQIASQPNAFAVAHALELCGSVDPVRLSAAIRQGLAEADTVQARF
GLNERGEPVQWLPSAADAANIRQPEWLDFSDPAQGEPAAWALMRADLAAPLPADGEQPLY
RQVIMRVSAQPERWFWYQRFHHLMVDGFSFDALTRRIATIYNALSAGETPEASPFAPFAE
VVAEYQAWERSPACRQAAAFWRDHAGELPTPVSLAADVCTPAPAGTRTLHQRVTLPAAPF
VALAQQRFGGKVQPAEVAMAALAAYLYRMSGEPRLSVGFPFMRRMGSAALCACGPVVNVL
PLQLTLQPDMTLIDVTQTLLAEIKAVRRHQRYEAEQLRRDLGLVGGSEGLYGPVMNFKVY
NAGLTLGNTPVTTHVLAMGPVDSLEFTLGVQDGELQLELVANPACYDSPALQGHAQRLQH
LLAQLVQQPDQAIGALRLLSDSEWRHIDGWGSGPQLTIPATLRSVLDCLQQQVRQQPDAL
AVACGKERLSYRELSARVMQLARLLMAQGIGTGDVVAIGVPRSVSSLVAIFGVLTSGAAY
MPLDLDYPRERLALMCDDARPALLLTHSAVRAQMPELPQVLCLDDATLRAECTRLPAHPV
TDAERREPLCGDHLAYMIYTSGSTGKPKGVMSTHAGLLNLMMSHSSFLFGPAIARFSQQQ
GRRLRAGHTASFSFDSSWEPLFCMMMGSELHIFDEELRKDAWALVQQFNQTPIDLMDITP
SFFTQMIDSGLLEADNHQPAFIMIGGEAATPRLWQLMRQHPQMEIHNYYGPSEYTIDTLG
ARVTVADQPVIGQPVANTRVWLLDNQLRPVPVGVPGELYIAGPGLARGYLRRPDLTATRF
VACPFMPGAVMYRTGDLMRWRHDGQLAFIGRVDHQIKVRGFRVELGEVENALVALAEVST
AVVIAEPLGATHRLIGYCSVPDAAAREQPDVAARLLAQLAEQLPDYMIPAVLMVMAELPL
TVNGKIDRQALPKPQQAAAVIGREAATEQERLICQSIASLLKLEMVSAEADFFALGGDSI
SAMGLGTLLRRAGWQLRPKAIFAERTPARMAQAMQPLTTVAVPLRTVRHGVVDGLPIVHG
FARLAGINQRFAHGVFLSVPDALQPAQLTQALTALAQAHPALTALTRDGQLVIDAASSTT
VSVISDTLTAQEPVDAAAERAFDAAVARLDPAAGRMMQAVLLQRDERACGLVLVVHHLVV
DGVSWRVLLPELRQAAEAAMAGRPAVLPAEECSLVDWSASLKEQVAARRAELPLWQSALA
APLPQLGQRRLDPSRDREQTRQLARRVLDAGLTHAVLTTLPERYQARVDEILLGALMLAC
HRRFGVQPLRLALESHGRIDTADGVDLGRTVGWLTAEYPVCIDAPAARAATPWAILRAVK
GALRAVPDRGVGYGVLRYLDAQSADALAALEDNAPEILFNYLGRFEAGEGPWSPRRSERY
FRDAFAVAPAPEMPLSHPLDINIFVDEQGEQPQLAIHWGWAHGVFDAEDIDALHQGMMQA
IEAWRDLAGSPPLSDTLVSADVAQDSVNDAVLERLRQRYGPLAAVLPVLPLQQGLLFHAQ
LADAAGSYNSLTRLSLRGPLSVAQLSQALEAVVRHHPQLAARFDTEQASAPLQVLPILRD
DQCYWPLDHQTLPAMPADEEADALLALEKAELARDLFHQPSSMLHALLVSHADGERHTLF
LNAHHLVVDGWSTPVCLRDLFTVLYQGSRALTPHAVPYTDIIRQLAARDADASRRRWRSV
LAGARPTLLFGDGTHHGDVRELELLPEPQLEQGLLALCKQYGLTLNSVMQGLWGMLLCAS
SGADDVLFGSPVSGRFGQIDGIGQQVGLFSNTLPVRVRLDAARALPPQLAELQAQQIQLI
EYDDVGLGEIQQLAGTGTLFDTLLVVENYPDGDVLSQAGQALRCEAVNNRGYTHYPLTLL
VLPGKRLRLLMEYRDGVAQPQRLAQRLLLLLEQLVAAPERPLSAWNLQLPEEQALLAAVN
RTEQPVPPGTLHQALAAQAQRTPERIALVDSRHQLTYRQVRHQTRLLADRLIDAGVRPGD
IVAVALPRSVRLSLALYAILETGAAWLPLDTGYPDERLALMVEDAQPRLMITESRLQPRF
AELADVLLLDTLADERQSPRHPSPPVAEQSSLVAEQQAAYVIYTSGSTGRPKGVVVGHQA
IVNRLWWMQHQYPLQANDVVLQKTPCSFDVSVWEFFWPLMVGARLVMAPPEAHRDPDALM
QLINDYAVTTLHFVPSMLAAWVSALETRSRAEIGCGSLRRVFCSGEALSRELALNYQSLI
AAPLHNLYGPTEAAVDVTWQPASGEALARCQLPGIPIGLPVWNTQLRILDGALRPAPVGV
PGDLYLCGVQLAQGYLRRPDLTASRFVADPFAAGERMYRTGDIARWLEDGTVDYLGRSDD
QLKIRGQRIELGEIEQALLAQPGVAQAVVGARELGGKPARLHGADARQLVAWLVPQAEIT
LDITALQQALSQQLPAHMVPVSYVLMTSFPLSANGKLDRKALPAPAGQQVAGRAPQTDSE
RTIAALFAELLACETVSADDDFFALGGHSLLAMRLAAEIRRQLQRSLTVGQIMAARSVAS
IAALVEGGADGNHPDGNGETLPLRPGRGPVLFCLHPASGFAWQYAGLLRYLEGDYPIVGL
QSPRPDGVIARCESVEAMCDRHLATMRRIQPQGPYFLLGYSLGGTLAHGIAARLQQAGET
VSFLGLLDTYPPEGQDWSAPDDADAREEVAREQAGFMADMQAGEDSPLRAERAAMFGNIV
ANYQDAVRLLSSARSSRFAGEATLFVATRTLPADMDVDATWAPYVSTLTPYPQRCEHADI
LSPASLENLGPLLNKLLTNSYVVL