Protein Info for DZA65_RS15285 in Dickeya dianthicola ME23

Annotation: phosphate acetyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13500: AAA_26
  • amino acids 5 to 227 (223 residues), 121.9 bits, E=4.9e-39
• PF07085: DRTGG
  • amino acids 233 to 344 (112 residues), 93.6 bits, E=9.8e-31
• PF01515: PTA_PTB
  • amino acids 391 to 706 (316 residues), 434.3 bits, E=5e-134
• TIGR00651: phosphate acetyltransferase
  • amino acids 406 to 706 (301 residues), 453.3 bits, E=2.4e-140

Best Hits

Swiss-Prot: 90% identical to PTA_YERPE: Phosphate acetyltransferase (pta) from Yersinia pestis

KEGG orthology group: K13788, phosphate acetyltransferase [EC: 2.3.1.8] (inferred from 98% identity to dze:Dd1591_1384)

MetaCyc: 85% identical to phosphate acetyltransferase (Escherichia coli K-12 substr. MG1655)
Phosphate acetyltransferase. [EC: 2.3.1.8]; PTAALT-RXN [EC: 2.3.1.8, 2.3.1.222]

Predicted SEED Role

"Phosphate acetyltransferase (EC 2.3.1.8)" in subsystem Ethanolamine utilization or Fermentations: Lactate or Fermentations: Mixed acid or MLST or Propanediol utilization or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Threonine anaerobic catabolism gene cluster (EC 2.3.1.8)

MetaCyc Pathways

• hexitol fermentation to lactate, formate, ethanol and acetate (19/19 steps found)
• mixed acid fermentation (15/16 steps found)
• superpathway of N-acetylneuraminate degradation (18/22 steps found)
• heterolactic fermentation (15/18 steps found)
• L-threonine degradation I (6/6 steps found)
• pyruvate fermentation to acetate and (S)-lactate I (4/4 steps found)
• pyruvate fermentation to acetate and lactate II (4/4 steps found)
• pyruvate fermentation to acetate I (3/3 steps found)
• pyruvate fermentation to acetate II (3/3 steps found)
• pyruvate fermentation to acetate IV (3/3 steps found)
• pyruvate fermentation to acetate VII (3/3 steps found)
• superpathway of acetate utilization and formation (3/3 steps found)
• acetate and ATP formation from acetyl-CoA I (2/2 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (7/9 steps found)
• acetylene degradation (anaerobic) (4/5 steps found)
• ethanolamine utilization (4/5 steps found)
• sulfoacetaldehyde degradation I (1/2 steps found)
• superpathway of Clostridium acetobutylicum acidogenic fermentation (6/9 steps found)
• (S)-propane-1,2-diol degradation (3/5 steps found)
• superpathway of L-threonine metabolism (12/18 steps found)
• superpathway of sulfolactate degradation (3/6 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (8/13 steps found)
• sulfolactate degradation II (1/4 steps found)
• acetyl-CoA fermentation to butanoate (3/7 steps found)
• methanogenesis from acetate (2/6 steps found)
• superpathway of L-alanine fermentation (Stickland reaction) (4/9 steps found)
• lactate fermentation to acetate, CO₂ and hydrogen (Desulfovibrionales) (3/8 steps found)
• superpathway of taurine degradation (1/6 steps found)
• L-lysine fermentation to acetate and butanoate (3/10 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (8/17 steps found)
• purine nucleobases degradation II (anaerobic) (13/24 steps found)
• gallate degradation III (anaerobic) (3/11 steps found)
• superpathway of methanogenesis (2/21 steps found)
• superpathway of L-lysine degradation (11/43 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Pyruvate metabolism
• Taurine and hypotaurine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.222 or 2.3.1.8

Sequence Analysis Tools

See A0A3A4D9H4 at UniProt or InterPro

Protein Sequence (713 amino acids)

>DZA65_RS15285 phosphate acetyltransferase (Dickeya dianthicola ME23)
MSRIIMLIPTGTSVGLTSVSLGVIRSMEQKGVRLSVFKPIAQPRSGESVLDQTTTIVRAT
SAIPAAEPLTMSYVESMLSSNQQDVLLEEIIARYHENTKDAEVVLVEGLVPTRKHQFANA
LNYEIAKTLNAEIVFVLALGNDSPAQLKERIDIARSSFGGSKNKNITGVIINKLNAPVDE
QGRTRPDLSEIFDDSTKASVANIDPKLLFANSPLPILGCVPWSFDLIATRAIDMANHLNA
RVINAGDIQTRRVKSVTFCARSIPHMLEHFRPGSLLVTSADRPDVLVAACLAAMNGVEIG
ALLLTGGYAIDPAISKLCERAFQTGLPVFMVDTNTWQTSLNLQSFNLELPPDDHERVEKV
QEYVARHIDTQWIDSLTAASERSRRLSPPAFRYQLTELARQASKRIVLPEGDEPRTVKAA
SICAERGIAQCVLLGNPDEIQRVAAAQGVELGKGIEIVDPIEARERYVPRLVELRKSKGM
TEVVAREQLEDNVVLGTLMLEQGEVDGLVSGAVHTTANTIRPPLQLIKTAPGSSLVSSVF
FMLLPEQVLVYGDCAINPDPTAEQLAEIAIQSADSAAAFGIEPRVAMISYSTGNSGAGSD
VDKVREATRLAQEKRPDLVIDGPLQYDAAIMADVAQSKAPNSPVAGKATVFVFPDLNTGN
TTYKAVQRSADLISIGPMLQGMRKPVNDLSRGALVDDIVYTVALTAIQATQIA