Protein Info for DZA65_RS13490 in Dickeya dianthicola ME23

Annotation: vitamin B12 ABC transporter ATP-binding protein BtuD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 257 PF00005: ABC_tran" amino acids 19 to 168 (150 residues), 83.8 bits, see alignment E=1.8e-27

Best Hits

Swiss-Prot: 63% identical to BTUD_PECAS: Vitamin B12 import ATP-binding protein BtuD (btuD) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K06074, vitamin B12 transport system ATP-binding protein [EC: 3.6.3.33] (inferred from 93% identity to ddd:Dda3937_03648)

Predicted SEED Role

"Vitamin B12 ABC transporter, ATPase component BtuD" in subsystem Coenzyme B12 biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.3.33

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CTY6 at UniProt or InterPro

Protein Sequence (257 amino acids)

>DZA65_RS13490 vitamin B12 ABC transporter ATP-binding protein BtuD (Dickeya dianthicola ME23)
MPDQPLLYLHNVSVAGRLSSVAVCCRPGELVHIIGPNGAGKSTLLALMAGLQPGDDGETR
LLGQSIAAWSARDLARVRAYLPQHHSALALMPVFQYLQLHQPAHCDADSVDTVVQQLAER
LSLTDKLRRPLTRLSGGEWQRVRLAAVLLQVWPTLNPSARLLLLDEPAASLDIAQRVALD
ALLAALCRAGVAVIASGHDLNHTLHHADRVWLMARGELMADGAAADVMQPEALSPVFGVA
FTRYALDGRHWMLAQQE