Protein Info for DZA65_RS12870 in Dickeya dianthicola ME23

Annotation: murein tripeptide amidase MpaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 243 PF24827: AstE_AspA_cat" amino acids 47 to 111 (65 residues), 25.8 bits, see alignment E=7.1e-10 PF00246: Peptidase_M14" amino acids 78 to 161 (84 residues), 40.1 bits, see alignment E=3.5e-14

Best Hits

Swiss-Prot: 69% identical to MPAA_ECO57: Murein peptide amidase A (mpaA) from Escherichia coli O157:H7

KEGG orthology group: K14054, protein MpaA (inferred from 96% identity to ddd:Dda3937_03135)

MetaCyc: 69% identical to murein tripeptide amidase A (Escherichia coli K-12 substr. MG1655)
RXN0-961

Predicted SEED Role

"Gamma-D-Glutamyl-meso-Diaminopimelate Amidase"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CY10 at UniProt or InterPro

Protein Sequence (243 amino acids)

>DZA65_RS12870 murein tripeptide amidase MpaA (Dickeya dianthicola ME23)
MTNAEFLHRPRTERGFFASPGQEYGRSRLGAPLLWFPAEVEGKHSGLILAGTHGDETASV
VALSCALRTLPPGGRAHHVVLAVNPDGCQLGLRANAGGVDLNRNFPAANWQPDGTLYRWS
EDTPVRDVQLSTGDHPGSEPETQALCRLIDRLSPPWVVSFHEPLACIDDPHRSELGSWLA
REFALPLVDSVGYPTPGSFGSWCAERHLQCITAELPVIAADSANHRYLTALTRLLSHNFL
YQC