Protein Info for DZA65_RS12620 in Dickeya dianthicola ME23

Annotation: aromatic acid/H+ symport family MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 448 transmembrane" amino acids 24 to 47 (24 residues), see Phobius details amino acids 59 to 79 (21 residues), see Phobius details amino acids 90 to 110 (21 residues), see Phobius details amino acids 116 to 137 (22 residues), see Phobius details amino acids 148 to 170 (23 residues), see Phobius details amino acids 177 to 197 (21 residues), see Phobius details amino acids 260 to 280 (21 residues), see Phobius details amino acids 296 to 316 (21 residues), see Phobius details amino acids 323 to 341 (19 residues), see Phobius details amino acids 345 to 364 (20 residues), see Phobius details amino acids 385 to 403 (19 residues), see Phobius details amino acids 410 to 432 (23 residues), see Phobius details PF07690: MFS_1" amino acids 30 to 282 (253 residues), 102.7 bits, see alignment E=3e-33 amino acids 262 to 429 (168 residues), 64 bits, see alignment E=1.8e-21 PF06779: MFS_4" amino acids 48 to 201 (154 residues), 31.4 bits, see alignment E=2.1e-11 PF00083: Sugar_tr" amino acids 60 to 298 (239 residues), 86.3 bits, see alignment E=3.3e-28

Best Hits

Swiss-Prot: 47% identical to PCAK_PSEAE: 4-hydroxybenzoate transporter PcaK (pcaK) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K08195, MFS transporter, AAHS family, 4-hydroxybenzoate transporter (inferred from 97% identity to ddd:Dda3937_03804)

Predicted SEED Role

"4-hydroxybenzoate transporter" in subsystem Cinnamic Acid Degradation or Gentisare degradation or Phenylpropanoid compound degradation or Salicylate and gentisate catabolism or p-Hydroxybenzoate degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4D2A3 at UniProt or InterPro

Protein Sequence (448 amino acids)

>DZA65_RS12620 aromatic acid/H+ symport family MFS transporter (Dickeya dianthicola ME23)
MTGSTAIDVRQLINQRPLGAYQKLIVFLCFCIIALDGMDIAIMGFIAPSLKTAWGIGNAE
LAVVISAALIGLAVGAMVSGPLADWRGRKTIIIASVFLFGLWTLLTAFSQTLQHMVIFRF
LTGLGLGAAMPNVGTLVSEFAPEKKRSFIITVVFCGFSFGAASGGFAASWMIPQWGWHSV
LLMGGILPLLLVPLLLMKLPESVRFLVSKRADSRQIHQIVDKIVPGISQADSRFAMPVAE
KTPAFAVQLVLSRAYRFGSVMLWGGYFFGLFMVYLLGSWLPTVIKEAGMSVTEATIITAL
YQAGGTFGSLFAGWLMDRVNPHLALGMIYAAGGVATAMIGFTHAYFVILAVVAFSSGFCL
NGANTGMNALSARYYPTEARATGSGWMHGVGRIGAIMSAFAGAQVVNMGWGLTTMFTILA
IPALLTSLMILAKGQFGYSRPAVAELSY