Protein Info for DZA65_RS12475 in Dickeya dianthicola ME23

Annotation: CAR family subclass B3 metallo-beta-lactamase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 342 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF00753: Lactamase_B" amino acids 94 to 220 (127 residues), 67.7 bits, see alignment E=1.4e-22 PF12706: Lactamase_B_2" amino acids 108 to 262 (155 residues), 32 bits, see alignment E=9.4e-12

Best Hits

KEGG orthology group: None (inferred from 91% identity to ddd:Dda3937_03789)

Predicted SEED Role

"metallo-beta-lactamase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385Y1M8 at UniProt or InterPro

Protein Sequence (342 amino acids)

>DZA65_RS12475 CAR family subclass B3 metallo-beta-lactamase (Dickeya dianthicola ME23)
MRLIMLKKYLLSYVTAGLLAAPGTSALAQTPLSSHAAAPQSLAGCPSDAINARFTEFGRT
GRMPPDLNQWLNDPQAQAIPPYQAFDNVYFVGVCWVSAWLVKTSGGPVLIDTLHEPYVDQ
LIANIRQVGVDPADIKLVLMTHGHFDHVGGAYKINALSQARFVMTQAGWDEALEDARQSQ
HSPRPWKMLDNADIVAQDGQTFTVGDTTFYAYATPGHTWGTTSYAFDVKDGDTTYRAITI
GGMGLNAIENTRQVQAYLASVDRLKRLITDPQHPITVHLTAHPFNTGLTEAKARLKTRQP
GDPHPLVDQAALIKQMDNARDAAEQRLIAEQKKEQENTRQAP