Protein Info for DZA65_RS12405 in Dickeya dianthicola ME23
Annotation: 4-aminobutyrate--2-oxoglutarate transaminase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 71% identical to PUUE_ECOLI: 4-aminobutyrate aminotransferase PuuE (puuE) from Escherichia coli (strain K12)
KEGG orthology group: K00823, 4-aminobutyrate aminotransferase [EC: 2.6.1.19] (inferred from 98% identity to ddd:Dda3937_04150)MetaCyc: 71% identical to 4-aminobutyrate aminotransferase PuuE (Escherichia coli K-12 substr. MG1655)
5-aminovalerate transaminase. [EC: 2.6.1.48]; 4-aminobutyrate transaminase. [EC: 2.6.1.48, 2.6.1.19]
Predicted SEED Role
"Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)" (EC 2.6.1.19)
MetaCyc Pathways
- 4-aminobutanoate degradation III (2/2 steps found)
- 4-aminobutanoate degradation I (1/2 steps found)
- 4-aminobutanoate degradation II (1/2 steps found)
- superpathway of 4-aminobutanoate degradation (1/3 steps found)
- L-lysine degradation X (3/6 steps found)
- GABA shunt I (1/4 steps found)
- GABA shunt II (1/4 steps found)
- L-lysine degradation I (3/7 steps found)
- L-lysine degradation IV (1/5 steps found)
- L-lysine degradation III (1/6 steps found)
- superpathway of L-arginine and L-ornithine degradation (6/13 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (4/11 steps found)
- 4-aminobutanoate degradation V (1/7 steps found)
- nicotine degradation I (pyridine pathway) (5/17 steps found)
- superpathway of L-lysine degradation (11/43 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Butanoate metabolism
- Glutamate metabolism
- Lysine degradation
- Propanoate metabolism
- beta-Alanine metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.6.1.19 or 2.6.1.48
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A3A4DFR2 at UniProt or InterPro
Protein Sequence (421 amino acids)
>DZA65_RS12405 4-aminobutyrate--2-oxoglutarate transaminase (Dickeya dianthicola ME23) MSNSELNQRRLAATPRGVGVMCDFFADKAENATLWDVEGREYIDFAAGIAVLNTGHRHPK LMAAVREQLEKFTHTAYQIVPYGSYVTLAERLNALAPIAGPAKTAFFTTGAEAVENAVKI ARAYTKRPGVIAFGAAFHGRTLLTLTLTGKVAPYSTGFGPFPGSIFHALYPNAQHGITVE QALDSIDRLLHTDIAADQVAAILLEPVQGEGGFIVAPPEFISGVRQLCDKHGMLLIADEV QTGFARTGKVFAMEYYDDKADLITMAKSLGGGFPISGVVGRAEVMDAPGPGGLGGTYAGN PLAVASALAVLDVIEEEQLCQRAQRLGATLVEALERAKADNPAIADIRARGSMVAVEFND PQTGKPSAEITKKYQQAALEQGLLLLTCGTHGNVIRFLYPLTIPDTQFSKALSILTRVLA K