Protein Info for DZA65_RS12400 in Dickeya dianthicola ME23

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 20 to 477 (458 residues), 567.9 bits, E=7.1e-175
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 30 to 476 (447 residues), 726.9 bits, E=4.7e-223

Best Hits

Swiss-Prot: 65% identical to GABD_ECOLI: Succinate-semialdehyde dehydrogenase [NADP(+)] GabD (gabD) from Escherichia coli (strain K12)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 96% identity to dze:Dd1591_1868)

MetaCyc: 69% identical to NAD(P)+-dependent succinate semialdehyde dehydrogenase monomer (Cupriavidus necator H16)
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]; RXN-10823 [EC: 1.2.1.16]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• 4-aminobutanoate degradation III (2/2 steps found)
• L-lactaldehyde degradation (aerobic) (1/2 steps found)
• homotaurine degradation (1/2 steps found)
• superpathway of fucose and rhamnose degradation (8/12 steps found)
• methylglyoxal degradation IV (1/3 steps found)
• methylglyoxal degradation V (1/3 steps found)
• lactate biosynthesis (archaea) (2/5 steps found)
• superpathway of methylglyoxal degradation (4/8 steps found)
• L-rhamnose degradation II (2/8 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Pyruvate metabolism
• Tyrosine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.22

Sequence Analysis Tools

See A0A385XYR6 at UniProt or InterPro

Protein Sequence (486 amino acids)

>DZA65_RS12400 NAD-dependent succinate-semialdehyde dehydrogenase (Dickeya dianthicola ME23)
MQLKNKTLFRQQSLIGGEWQDSFNGARLSVTNPATGTELGSIPLVTAEQTQQAITAAEQA
LSAWRQRTGKERAALMQAWAHLIRANQDDLAAILTAEQGKSLAEASGEIAYATSFIDWFA
EEAKRVEGSVLQSPQANQRLLVIKQGIGVCAAITPWNFPAAMITRKAAPALAAGCTMIIK
PAEQTPFTALALAELAQQAGIPAGVLQVVTGDAPAVGKVLCDSPVVRKLSFTGSTEVGRL
LMAQCAPTVKKLSLELGGNAPFIVFDDADLEQAIKGILASKFRNSGQTCVCANRIYVQRG
IYPALAARLVEEVEKLKVGDGTQPGVMQGPLIDQDAVGKVEQHIDDALSKGAELLTGGSR
HALGGTFFTPTVIGGVTRDMRFAREETFGPVAPLFPFDDEAQAVAMANDTEFGLAAYVYT
RDAIRQWRVPEALEYGMVGINTGLISNEVAPFGGVKQSGLGREGSRFGIEEYLEMKYLCV
DLTPSA