Protein Info for DZA65_RS11635 in Dickeya dianthicola ME23

Annotation: aminodeoxychorismate synthase component 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF04715: Anth_synt_I_N
  • amino acids 17 to 153 (137 residues), 90 bits, E=1.7e-29
• TIGR00553: aminodeoxychorismate synthase, component I
  • amino acids 106 to 443 (338 residues), 428.9 bits, E=6.3e-133
• PF00425: Chorismate_bind
  • amino acids 189 to 442 (254 residues), 294.4 bits, E=8.4e-92

Best Hits

Swiss-Prot: 71% identical to PABB_KLEAE: Aminodeoxychorismate synthase component 1 (pabB) from Klebsiella aerogenes

KEGG orthology group: K01665, para-aminobenzoate synthetase component I [EC: 2.6.1.85] (inferred from 93% identity to ddd:Dda3937_03719)

MetaCyc: 68% identical to aminodeoxychorismate synthase subunit 1 (Escherichia coli K-12 substr. MG1655)
Aminodeoxychorismate synthase. [EC: 2.6.1.85]

Predicted SEED Role

"Para-aminobenzoate synthase, aminase component (EC 2.6.1.85)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Folate Biosynthesis (EC 2.6.1.85)

MetaCyc Pathways

• superpathway of chorismate metabolism (54/59 steps found)
• superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
• superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• 4-aminobenzoate biosynthesis I (2/2 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (3/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (3/4 steps found)
• L-glutamate and L-glutamine biosynthesis (5/7 steps found)
• L-citrulline biosynthesis (5/8 steps found)
• superpathway of L-citrulline metabolism (7/12 steps found)
• superpathway of candicidin biosynthesis (4/11 steps found)
• chloramphenicol biosynthesis (1/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of phenylpropanoids
• Folate biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.85

Use Curated BLAST to search for 2.6.1.85

Sequence Analysis Tools

See A0A385XXN6 at UniProt or InterPro

Protein Sequence (456 amino acids)

>DZA65_RS11635 aminodeoxychorismate synthase component 1 (Dickeya dianthicola ME23)
MPTSIVYHALPYQPDALLRLFSSLSRQPWAMLLHSGFADHPHNRFDILVAEPRLTLQTVG
ELTTLQHGDARQTSAEDPFHLLQQQLDALALNVPPHPDYPFQGGALGLFGYDLGRRVEQL
PAIAERDIDLPDMAVGIYDWALIADHHQQRLTLVTHGDSEARLAWLNSLSPAEPGAFCLT
SDWQANMSRAQYGEKFRRIQDYLHAGDCYQVNLTQRFQATYHGDEWQAFLTLSASNRAPF
SAFLRLPHSAVLSISPERFLWLHDGCIQARPIKGTLPRLPDADADARQAQRLAASEKDRA
ENLMIVDLLRNDIGRVAVPGSVRVPELFVVEPFPAVHHLVSTIEARLPAQQHATGVLRAC
FPGGSITGAPKVRAMEIIEELEPHRRNAYCGSIGYLSVCGTMDTNITIRTLIAANGTLSC
WAGGGIVADSEEQAEYQETFDKIGRILPLLTVSTTD