Protein Info for DZA65_RS10995 in Dickeya dianthicola ME23

Annotation: protease SohB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 348 transmembrane" amino acids 6 to 30 (25 residues), see Phobius details amino acids 166 to 183 (18 residues), see Phobius details amino acids 189 to 207 (19 residues), see Phobius details PF08496: Peptidase_S49_N" amino acids 2 to 157 (156 residues), 191.6 bits, see alignment E=8e-61 PF01343: Peptidase_S49" amino acids 160 to 306 (147 residues), 160.7 bits, see alignment E=2.7e-51

Best Hits

Swiss-Prot: 67% identical to SOHB_SHIFL: Probable protease SohB (sohB) from Shigella flexneri

KEGG orthology group: K04774, serine protease SohB [EC: 3.4.21.-] (inferred from 97% identity to ddd:Dda3937_00583)

Predicted SEED Role

"Possible protease sohB (EC 3.4.21.-)" (EC 3.4.21.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XZJ3 at UniProt or InterPro

Protein Sequence (348 amino acids)

>DZA65_RS10995 protease SohB (Dickeya dianthicola ME23)
MELLSQYGLFLAKVVTLVVAIGALVVLTVGMTQRKRHRKGELQVINLGEQYREMRREMQS
AAMSDTVRSLLEKKQKKEEKETAKQEKKRAKRGEEKSARPCLYVLDFNGSMDAGEVSSLR
EEVSAVLAVAQPEDEVLLRLESPGGVVHGYGLAASQLQRFRQRGIRLTVAVDKVAASGGY
MMACVADRIVAAPFAIVGSIGVVAQIPNFNRLLKSKDIDVELHTAGQYKRTLTLFGENTE
EGREKFREELNETHLLFKQFVSEMRPSLDIESVATGEHWFGTQARAMGLVDAIGTSDDLL
ITEMENHEVLAVRYTRRKRLLDRLTGSTSDALERLMLRWWQRGNNPPL