Protein Info for DZA65_RS09695 in Dickeya dianthicola ME23
Annotation: GTP cyclohydrolase I FolE
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 92% identical to GCH1_PECCP: GTP cyclohydrolase 1 (folE) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)
KEGG orthology group: K01495, GTP cyclohydrolase I [EC: 3.5.4.16] (inferred from 98% identity to ddd:Dda3937_03497)MetaCyc: 89% identical to GTP cyclohydrolase 1 (Escherichia coli K-12 substr. MG1655)
GTP cyclohydrolase I. [EC: 3.5.4.16]
Predicted SEED Role
"GTP cyclohydrolase I (EC 3.5.4.16) type 1" in subsystem Folate Biosynthesis or Molybdenum cofactor biosynthesis or Pterin biosynthesis or Queuosine-Archaeosine Biosynthesis (EC 3.5.4.16)
MetaCyc Pathways
- superpathway of chorismate metabolism (54/59 steps found)
- superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
- superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
- 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I (4/5 steps found)
- preQ0 biosynthesis (3/4 steps found)
- drosopterin and aurodrosopterin biosynthesis (5/7 steps found)
- 6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium) (2/3 steps found)
- erythro-tetrahydrobiopterin biosynthesis I (2/4 steps found)
- threo-tetrahydrobiopterin biosynthesis (2/4 steps found)
- tetrahydromonapterin biosynthesis (1/4 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 3.5.4.16
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A3A4CUP7 at UniProt or InterPro
Protein Sequence (234 amino acids)
>DZA65_RS09695 GTP cyclohydrolase I FolE (Dickeya dianthicola ME23) MSAVLTKSAVLTRSAILTKEATQVHEALLARGLETPLRGKMLESETRKRLIAEHMTEIMN LLNLDLADDSLAETPHRIAKMYVEEIFSGLDYANFPKITIIENKMKVDEMVTVRDITLTS TCEHHFVTIDGKATVAYIPKEGVIGLSKINRIVQFFSQRPQVQERLTQQILVALQTLLGT NNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHQN