Protein Info for DZA65_RS07435 in Dickeya dianthicola ME23

Annotation: As(III)-sensing metalloregulatory transcriptional repressor ArsR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 116 PF12840: HTH_20" amino acids 12 to 59 (48 residues), 32.6 bits, see alignment E=6.2e-12 PF01022: HTH_5" amino acids 14 to 59 (46 residues), 63.5 bits, see alignment E=1.3e-21

Best Hits

Swiss-Prot: 90% identical to ARSR1_ECOLX: Arsenical resistance operon repressor (arsR) from Escherichia coli

KEGG orthology group: K03892, ArsR family transcriptional regulator (inferred from 94% identity to esc:Entcl_2215)

MetaCyc: 75% identical to DNA-binding transcriptional repressor ArsR (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Arsenical resistance operon repressor" in subsystem Arsenic resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4C6U9 at UniProt or InterPro

Protein Sequence (116 amino acids)

>DZA65_RS07435 As(III)-sensing metalloregulatory transcriptional repressor ArsR (Dickeya dianthicola ME23)
MSLTALQLFKNLSDETRLGIVLLLREMGELCVCDLCTALDQSQPKISRHLAMLRESGLLL
DRKQRKWVHYRLSPHIPSWAAQVIEQAWLSQQDDVQAIARKLVSANCSGSGKAVCI