Protein Info for DZA65_RS06875 in Dickeya dianthicola ME23

Annotation: cytochrome d ubiquinol oxidase subunit II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 379 transmembrane" amino acids 12 to 36 (25 residues), see Phobius details amino acids 57 to 75 (19 residues), see Phobius details amino acids 81 to 100 (20 residues), see Phobius details amino acids 120 to 142 (23 residues), see Phobius details amino acids 164 to 188 (25 residues), see Phobius details amino acids 203 to 226 (24 residues), see Phobius details amino acids 264 to 283 (20 residues), see Phobius details amino acids 291 to 315 (25 residues), see Phobius details amino acids 335 to 360 (26 residues), see Phobius details TIGR00203: cytochrome d ubiquinol oxidase, subunit II" amino acids 1 to 379 (379 residues), 623.2 bits, see alignment E=9.3e-192 PF02322: Cyt_bd_oxida_II" amino acids 7 to 362 (356 residues), 362 bits, see alignment E=1.4e-112

Best Hits

Swiss-Prot: 78% identical to CYDB_ECO57: Cytochrome bd-I ubiquinol oxidase subunit 2 (cydB) from Escherichia coli O157:H7

KEGG orthology group: K00426, cytochrome bd-I oxidase subunit II [EC: 1.10.3.-] (inferred from 98% identity to dze:Dd1591_2909)

MetaCyc: 78% identical to cytochrome bd-I subunit 2 (Escherichia coli K-12 substr. MG1655)
RXN0-5266 [EC: 7.1.1.7]; 1.11.1.- [EC: 7.1.1.7]; 1.11.1.- [EC: 7.1.1.7]

Predicted SEED Role

"Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-)" in subsystem Bacterial RNA-metabolizing Zn-dependent hydrolases or Conserved gene cluster associated with Met-tRNA formyltransferase or Terminal cytochrome d ubiquinol oxidases or Terminal cytochrome oxidases (EC 1.10.3.-)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.10.3.-

Use Curated BLAST to search for 1.10.3.- or 7.1.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XV48 at UniProt or InterPro

Protein Sequence (379 amino acids)

>DZA65_RS06875 cytochrome d ubiquinol oxidase subunit II (Dickeya dianthicola ME23)
MFDYEVLRFVWWLLIGVLLIGFAVTDGFDMGVGILVRLMGRNDVERRVMINSIAPHWDGN
QVWLITAGGALFAAWPMVYAAAFSGFYIAMILVLASLYFRPVGFDYRSKIEDPRWRNMWD
WGIFIGSFVPPVVIGVAFGNLLQGVPFHVDEYLRLYYTGNFFQLLNPFGLLAGVVSLSMI
VAQGATYLVMRTSGDLHFRAKKVAQFSSLALTVTFALAGVWVVYGIDGYAVTSVINTAGE
SNPLHKEVARQAGAWLVNFNHHPVLWAVPLLGVVLPLMTAVMARAEKGAMAFLFSSLSIA
CVILTAGIAMFPFIMPSVTVPNVSLTIWDATSSLLTLRVMTVVAIIFVPIVLSYTIWCYY
KMFGRITKEHVEQNSHSLY