Protein Info for DZA65_RS06760 in Dickeya dianthicola ME23

Annotation: two-component system sensor histidine kinase KdbD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 909 transmembrane" amino acids 402 to 424 (23 residues), see Phobius details amino acids 430 to 447 (18 residues), see Phobius details amino acids 453 to 472 (20 residues), see Phobius details amino acids 481 to 502 (22 residues), see Phobius details PF02702: KdpD" amino acids 23 to 231 (209 residues), 322.1 bits, see alignment E=3.5e-100 PF13493: DUF4118" amino acids 406 to 512 (107 residues), 99.8 bits, see alignment E=1.9e-32 PF13492: GAF_3" amino acids 531 to 653 (123 residues), 56.7 bits, see alignment E=8.8e-19 PF00512: HisKA" amino acids 673 to 738 (66 residues), 45.1 bits, see alignment 2.1e-15 PF02518: HATPase_c" amino acids 784 to 897 (114 residues), 102.2 bits, see alignment E=5.8e-33

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 98% identity to ddd:Dda3937_01552)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XX49 at UniProt or InterPro

Protein Sequence (909 amino acids)

>DZA65_RS06760 two-component system sensor histidine kinase KdbD (Dickeya dianthicola ME23)
MTDEEQRRPDPDSLLSQIEEQPRGKLKIFFGACAGVGKTYAMLQEAQRLKAQGLDVLVGV
VETHGRSETAALVEGLPHLPMKKINHYGRHHHEFDLDAALARCPALILIDELAHSNIRGS
RHPKRWQDVQELLDAGIDVFTTVNVQHLESLNDIVGGVTGIRVRETVPDPIFDDANEVVL
VDLPPDDLRQRLNEGKVYLPMQAERAIENFFRKGNLLALRELALRRMADRVDDQMRAMRA
SQGRERVWHTRDAILLCIGRGVGNEKLVRTAARLAARLGSIWHAVYVETPRLHRLPEGER
RAILRALKLAQDLGAETATLSDPSVERAVLRYARERNLGKIVIGRHPEQKLGWWRRTRFA
EKLGKLGPDLDLVVVSVQDDAAPPPPKTPDVRGMTDKWRLQFYGCGVAALLCTLITLLAL
WSPFSMLEPVNLVMLYLLAVVIIALFYGRWPSVFAAVINVASFDLFFVVPKGTFAVADVQ
YLVTFAVMLTIGILVGNLTAGVRYQARVARYREQRVRHLYEMSRALNRSLSVQDIAKASH
HFLRSTFQAKIAILLAEPVSSPTAELQQAALDEPDQLIVDQAIARWSYDHAAPAGAGTTT
LPGVPYQLMPLATPQLSFGVIAIEPNNVRQLMIPEQQRMLETFMVLIANALERLHLVRST
ENARLDAEREQLRNSLLAALSHDLRTPLTVLFGQAEILTLNLASEGSPYAPQASQIRQHI
LSTTRLVNNLLDMARIQSDGFNLRKEWQTLEELAGSALRQLENSLANNTIQLRLPQDMIL
VYCDASLIERVLINLLENAIKYAGEQATITVAASRISSPASGDMLEVQVRDNGPGIPDGQ
EKVIFDKFARGHKESSIPGVGLGLAICRAIVEIHGGRIWATNADDGGAVFHFTLPLAPPP
ALEPEEMES