Protein Info for DZA65_RS06270 in Dickeya dianthicola ME23

Annotation: two-component system sensor histidine kinase RcsC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 954 transmembrane" amino acids 19 to 39 (21 residues), see Phobius details amino acids 308 to 311 (4 residues), see Phobius details amino acids 313 to 337 (25 residues), see Phobius details PF00512: HisKA" amino acids 471 to 535 (65 residues), 66.3 bits, see alignment 4.1e-22 PF02518: HATPase_c" amino acids 582 to 693 (112 residues), 94 bits, see alignment E=1.7e-30 PF09456: RcsC" amino acids 712 to 802 (91 residues), 106.4 bits, see alignment E=1.1e-34 PF00072: Response_reg" amino acids 831 to 939 (109 residues), 106.4 bits, see alignment E=2e-34

Best Hits

KEGG orthology group: K07677, two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC: 2.7.13.3] (inferred from 94% identity to ddd:Dda3937_01775)

Predicted SEED Role

"Two-component sensor protein RcsC (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XWV2 at UniProt or InterPro

Protein Sequence (954 amino acids)

>DZA65_RS06270 two-component system sensor histidine kinase RcsC (Dickeya dianthicola ME23)
MPLKVTASFQTTLKVSRYMFRALATTLWILGALISVFYVNKELNQRESHLRQIFSLNFEQ
SLGYIRHTTDVARELRYIAANRFSAPVALRERGAAAKKTPFAIYRLSSTFDCGEQYEKNL
AQLQSLTGFFDQWHDDFSSVYDLNRIFFVDSSQQCIVDFGIRNQSLDSDSLMKSVQERLQ
NQKSNWIGNRREESLFWVTPGPTPDSGYLYALTPVYVDNHLVTMMGIEQTIRLDDVMLNG
DLPFSVRLLDQNDRVLLQFTDNQPGNNLSHYPDSNNYFGYSDGYGVLLMKKALPPTSMTV
VYSLPLDVILMSLNTLIINIVLLNLASAICLFLLTRLFERKIFLPAERNAFQLEENEQFN
RKIVASAPVGICILRISDGTNILSNELAHNYLSLLTYEDRVRIVRIICEQQSKSLDVVTG
RNHHLQISFVHSRYRNENVAICVLLDVSARVRMEESLQEMANAAEQASQSKSMFLATVSH
ELRTPLYGIIGNLDLLQTKLLPSDANRLVTAMQNSSSLLLKIISDILDFSKIESEQLKIE
PSEFAPREVINHIVSNYLPLVVKKRLVLYCYIDPDVPFRLMGDAVRLQQVLSNLLSNAIK
FTDTGCIVFQVACCDDGYLVFKVRDTGVGIDTRAVMKLFDPFFQAGTGVQRHFQGTGLGL
AICEKLVSLMDGDITIESELGLGSEFGIRIPLYRAHYPQTLPVPDLQGKTYWLQIRNALM
ERYLLGLLNTGGLDAQRYEEGQPVGRDDVMIFDHVPDTLPNAYAWVEISGMQAGAAQEIR
TGYWLYSTAALHELPVLLQRIYRGEDELPTAALSLPSVSYNRTENGGIRLLVVDDHPINR
RLLADQLGSLGYQVVTANDGLDALDVLAKNPVDIVLTDVNMPNMDGYRFTQRLREMGQTL
PVIGVTANALAEERQRCLQAGMDNCLSKPVTLDTLQQSLSYYSNSVRQNKAVQS