Protein Info for DZA65_RS06255 in Dickeya dianthicola ME23
Annotation: ribonucleoside-diphosphate reductase subunit alpha
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 89% identical to RIR1_ECOLI: Ribonucleoside-diphosphate reductase 1 subunit alpha (nrdA) from Escherichia coli (strain K12)
KEGG orthology group: K00525, ribonucleoside-diphosphate reductase alpha chain [EC: 1.17.4.1] (inferred from 99% identity to ddd:Dda3937_04165)MetaCyc: 89% identical to ribonucleoside-diphosphate reductase 1 subunit alpha (Escherichia coli K-12 substr. MG1655)
Predicted SEED Role
"Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)" in subsystem Ribonucleotide reduction (EC 1.17.4.1)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (26/26 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (14/14 steps found)
- superpathway of purine nucleotide salvage (13/14 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
- superpathway of guanosine nucleotides de novo biosynthesis II (8/8 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis II (7/7 steps found)
- superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
- adenosine deoxyribonucleotides de novo biosynthesis II (4/4 steps found)
- guanosine deoxyribonucleotides de novo biosynthesis II (4/4 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
- adenosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
- guanosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
- pyrimidine deoxyribonucleotides biosynthesis from CTP (6/8 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.17.4.1
Use Curated BLAST to search for 1.17.4.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A385XUV4 at UniProt or InterPro
Protein Sequence (762 amino acids)
>DZA65_RS06255 ribonucleoside-diphosphate reductase subunit alpha (Dickeya dianthicola ME23) MNQSLLVTKRDGSKERINLDKIHRVITWAAEGLHNVSVSQVELRSHIQFYDGIKTADIHE TIIKAAADLISRESPDYQYLAARLAIFHLRKKAYGQFEPPKLHDHIVKMVEMGKYDRHLL EDYTEDEFAQMDAFIDHWRDMNFSYAAVKQLEGKYLVQNRVTGDIYESAQFLYILVAACL FSGYPRETRLDYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINAT SSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG AATLFYPLWHLEVESLLVLKNNRGVEGNRVRHLDYGVQLNKLMYQRLVKGEDITLFSPSD VPGLYDAFFTNQDEFERLYVKYEQDGSIRKTQLKATELFSLMMQERASTGRIYIQNVDHC NTHSPFDPLVAPVRQSNLCLEIALPTKPLEDVNDESGEIALCTLSAFNLGAISSLHELEE LAALAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGVRYSDGSANNLT HRTFEAIQYYLLKASNQLAREQGACPWFNETTYSQGILPIDSYKRDLDGICSEPLHYDWE TLRKDIQTYGLRNSTLSALMPSETSSQISNATNGIEPPRGHISVKASKDGILRQVVPEYE TLKDAYELLWDMPSNDGYLQLVGLMQKFVDQAISSNTNYDPARFPSGKVPMTQLLKDLLT AYKFGLKTLYYQNTRDGAEDAQDDLLDTAPQDDGCESGACKI