Protein Info for DZA65_RS06225 in Dickeya dianthicola ME23

Annotation: copper-exporting P-type ATPase CopA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 938 transmembrane" amino acids 281 to 299 (19 residues), see Phobius details amino acids 311 to 332 (22 residues), see Phobius details amino acids 344 to 366 (23 residues), see Phobius details amino acids 378 to 396 (19 residues), see Phobius details amino acids 530 to 552 (23 residues), see Phobius details amino acids 558 to 580 (23 residues), see Phobius details amino acids 876 to 895 (20 residues), see Phobius details amino acids 901 to 920 (20 residues), see Phobius details PF00403: HMA" amino acids 8 to 62 (55 residues), 45 bits, see alignment 2.9e-15 amino acids 73 to 128 (56 residues), 38.6 bits, see alignment 2.8e-13 amino acids 199 to 253 (55 residues), 55.7 bits, see alignment 1.3e-18 TIGR01511: copper-translocating P-type ATPase" amino acids 327 to 925 (599 residues), 598 bits, see alignment E=5e-183 TIGR01525: heavy metal translocating P-type ATPase" amino acids 346 to 925 (580 residues), 585.3 bits, see alignment E=3.8e-179 TIGR01494: HAD ATPase, P-type, family IC" amino acids 385 to 894 (510 residues), 271 bits, see alignment E=3.8e-84 PF00122: E1-E2_ATPase" amino acids 414 to 594 (181 residues), 163.9 bits, see alignment E=7.5e-52 PF00702: Hydrolase" amino acids 612 to 830 (219 residues), 125.8 bits, see alignment E=7.1e-40 PF08282: Hydrolase_3" amino acids 803 to 862 (60 residues), 30 bits, see alignment 1.1e-10

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 94% identity to ddd:Dda3937_04159)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CBX6 at UniProt or InterPro

Protein Sequence (938 amino acids)

>DZA65_RS06225 copper-exporting P-type ATPase CopA (Dickeya dianthicola ME23)
MSQTILLSLQGLSCEHCVGRVKKALEARPDVEQADVSLKYANVTGEADSQSLVATIEAAG
YEASPATTPNVTLLLSGLNCQHCVASTRKALEAVPGVAATDVTLQQATVYGDAEPQALVQ
AIEQAGFHAALAQENTLPKSEPLTPHASSPDRLSAAFDSVPANTVRDDNVAHDNGSVHDN
DSIHDSDNAHDNDSVQLLLSGMSCASCVSRVQQALQRVPGVTQARVNLAERSALVSGNTS
HQALIDAVQNAGYGAEIILDEAERRARQEQTSRQSIRRFRWQAALGLALGIPLMVWSMIG
DNMMLTDDNRSGWLLVGGLTLAVMIAAGGHFYRNAWRSLLNGSATMDTLVALGTGAAWLY
SITVNLWPTWFPMEARHLYYEASAMIIGLINLGHALEQRARQRSSQALERLLDLTPPTAR
LVTPQGDRVIPLADVQTGMTLRLTTGDRIPVDGMLEQGELWIDEAMLTGEPIPQQKAAGD
KVHAGTQVQDGSATLRAGAIGNQTTLARIIHLVRQAQSSKPAIGQLADRISAVFVPVVVA
IALLSGAIWYVVGPAPHVVYTLVIATTVLIIACPCALGLATPMSIISGVGRAAELGVLVR
DADALQQASRLDVLVFDKTGTLTEGKPRVVAIQTFGDISESQALRWAASLEQGASHPLAQ
AIIQRADGVELSDVTQFRTLPGLGVSGQVDGASLLLGNPALLAQRQISLADGENAPRDGL
EKQSALGMTPVLLVANGQVAALFSVQDILRQDSVSALQRLHRQGYQLVMLTGDNPATAQA
IAREAGIDQVIAGVLPDGKADAIRHLQSQGKRVAMIGDGINDAPALAQADVGIAMGGGSD
IAVETAAMTLMRHSLHGVADALALSRATLANMKQNLLGAFVYNTLGIPIAAGVLYPLTGT
LLNPVVAGAAMALSSITVVSNANRLLRFTPADAPARRD