Protein Info for DZA65_RS06115 in Dickeya dianthicola ME23

Annotation: multidrug efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1049 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 394 to 414 (21 residues), see Phobius details amino acids 438 to 458 (21 residues), see Phobius details amino acids 471 to 497 (27 residues), see Phobius details amino acids 538 to 556 (19 residues), see Phobius details amino acids 870 to 889 (20 residues), see Phobius details amino acids 896 to 916 (21 residues), see Phobius details amino acids 923 to 945 (23 residues), see Phobius details amino acids 972 to 992 (21 residues), see Phobius details amino acids 1004 to 1026 (23 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1046 (1046 residues), 1809 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1027 (1027 residues), 1384.1 bits, see alignment E=0 PF03176: MMPL" amino acids 299 to 496 (198 residues), 30.8 bits, see alignment E=2.3e-11 PF02355: SecD_SecF" amino acids 868 to 1021 (154 residues), 24.5 bits, see alignment E=2.5e-09

Best Hits

Swiss-Prot: 77% identical to ACRB_ECOLI: Multidrug efflux pump subunit AcrB (acrB) from Escherichia coli (strain K12)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 68% identity to abo:ABO_0964)

MetaCyc: 77% identical to multidrug efflux pump RND permease AcrB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-356; TRANS-RXN-357; TRANS-RXN-359; TRANS-RXN0-592

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CE02 at UniProt or InterPro

Protein Sequence (1049 amino acids)

>DZA65_RS06115 multidrug efflux RND transporter permease subunit (Dickeya dianthicola ME23)
MAKFFIDRPIFAWVIAIMVMLTGTLAILKLPIAQYPTIAPPAVQITANYPGADAKTLQDT
VTQVIEQNMNGIDKLLYMSSNSDSSGTVQITLTFDADANPDIAQVQVQNKLQLAMPLLPQ
EVQQQGVSVQKSSSSFLMVLGFVSDDNNMTPQDIADFVGASIKDPISRVRGVGDTQLFGA
QYAMRIWLDPDKLNNYQLTTSDVVSAIQVQNNQIAAGQLGGTPPVPGQKLNASIIAQTRL
NSPEQFGNILLKVNQDGSQVRLNNVAHIELGGESYNVIARYNGRPAAGLGIKLATGANAL
DTASAVKEEITKLQPTFPAGLKVVYPYDTTPFVKISIHEVVKTLLEAIVLVFVVMYLFLQ
NFRATLIPTIAVPVVLLGTFAILSAFGYSINTLTMFAMVLAIGLLVDDAIVVVENVERVM
AEEGLSPKEATRKSMGQIQGALVGIALVLSAVFIPMAFSSGSTGAIYRQFSVTIVSSMVL
SVLVALILTPALCATILKPITNHGEKKGFFGWFNRLFDKSTRHYTNSVANILRSTGRYVV
VYLLVVAGLGLMVTRLPSSFLPQEDQGVLLTMIQLPVGATQESTQKVLAQVNDYYLNSEK
DNVKSVFTVNGFGFAGRGQNMGIAFASLKDWDERSGAANKVDAIIGRAFGAFSQIKEAMV
IPFNLPAIIELGTASGFDFELIDQNNLGHDKLIAARNQLLGMIAQHPDTLVRVRPNGMED
MPQYRLEIDQEKAESLGVSISTINATLSTALGGTYVNDFIDRGRVKKVYVQAEAKFRMLP
NDIQKWYVRGTSGQMVPFSAFASSHWEYGSPRLERYNGLPSVELVGEAAPGKSTGEAMAL
MEELATQLPPGIGFDWTGMSYQERLAGNQAPALIIISAIVVFLCLAALYESWSIPFSVML
VVPLGVFGAVMAASLRGLENDVYFKVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGLVEA
TLDAVRMRLRPILMTSLAFILGVAPLVISSGAGSGAQNAVGTGVMGGMITATVLAIYFVP
VFFVVVRRRFSKKKEADDDSLHEHSQTSH