Protein Info for DZA65_RS05750 in Dickeya dianthicola ME23

Annotation: HAD family hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01490: HAD hydrolase, family IB
  • amino acids 3 to 201 (199 residues), 172.1 bits, E=1.7e-54
• TIGR01488: HAD phosphoserine phosphatase-like hydrolase, family IB
  • amino acids 3 to 188 (186 residues), 88.1 bits, E=6.9e-29
• PF12710: HAD
  • amino acids 4 to 188 (185 residues), 118.3 bits, E=2.9e-38

Best Hits

KEGG orthology group: None (inferred from 96% identity to ddd:Dda3937_01927)

Predicted SEED Role

"Phosphoserine phosphatase (EC 3.1.3.3)" in subsystem Glycine and Serine Utilization or Serine Biosynthesis (EC 3.1.3.3)

MetaCyc Pathways

• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• superpathway of L-serine and glycine biosynthesis I (4/4 steps found)
• L-serine biosynthesis I (3/3 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.3

Use Curated BLAST to search for 3.1.3.3

Sequence Analysis Tools

See A0A385XWK2 at UniProt or InterPro

Protein Sequence (218 amino acids)

>DZA65_RS05750 HAD family hydrolase (Dickeya dianthicola ME23)
MDLALFDLDETLICADSTGLWLRWLESQGFAGAELLQREQHLMQSYYQGTLAIEDYMYLS
LSPLIGLSTETVSVWVDRFIRRDILPRLYPAARERMDWHHQRGDTLVIISASGEHLVQPI
AHHLGANHALAIGVTLEDGRFTGDIHGVPTYQHGKVTRIREWLAHRDGEPFDQLHGYSDS
LNDRAMLEFVDQAYAVNPAPELAALAQEKGWRICRWQR