Protein Info for DZA65_RS04250 in Dickeya dianthicola ME23

Annotation: nucleotide exchange factor GrpE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 195 PF01025: GrpE" amino acids 38 to 192 (155 residues), 166 bits, see alignment E=2.9e-53

Best Hits

Swiss-Prot: 80% identical to GRPE_PECCP: Protein GrpE (grpE) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)

KEGG orthology group: K03687, molecular chaperone GrpE (inferred from 96% identity to ddd:Dda3937_02545)

MetaCyc: 59% identical to nucleotide exchange factor GrpE (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Heat shock protein GrpE" in subsystem Heat shock dnaK gene cluster extended or Protein chaperones

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4D5B9 at UniProt or InterPro

Protein Sequence (195 amino acids)

>DZA65_RS04250 nucleotide exchange factor GrpE (Dickeya dianthicola ME23)
MSSKEQKSPDEQVLDQKEAAEGQQADAVPETTAVADPRDERIAELEAQLNDAQQRERESA
LRARAEMENVRRRAELDVEKAHKFALEKFAGEILPVIDNLERALEMADKSNDALSGMIEG
VELTLKAMLSAVNKFGIEVVADVNVSFNPEIHQAMTLLESADHAPNHVMMVMQKGYTLNG
RLLRPAMVAVSKAKE