Protein Info for DZA65_RS02980 in Dickeya dianthicola ME23

Annotation: altronate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 496 PF08666: SAF" amino acids 11 to 80 (70 residues), 38.6 bits, see alignment E=1.9e-13 PF04295: GD_AH_second" amino acids 112 to 245 (134 residues), 164.6 bits, see alignment E=2e-52 PF20629: GD_AH_C" amino acids 256 to 495 (240 residues), 340.3 bits, see alignment E=8.6e-106

Best Hits

Swiss-Prot: 80% identical to UXAA_ECOLI: Altronate dehydratase (uxaA) from Escherichia coli (strain K12)

KEGG orthology group: K01685, altronate hydrolase [EC: 4.2.1.7] (inferred from 98% identity to ddd:Dda3937_02741)

MetaCyc: 80% identical to D-altronate dehydratase (Escherichia coli K-12 substr. MG1655)
Altronate dehydratase. [EC: 4.2.1.7]

Predicted SEED Role

"Altronate dehydratase (EC 4.2.1.7)" (EC 4.2.1.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XT16 at UniProt or InterPro

Protein Sequence (496 amino acids)

>DZA65_RS02980 altronate dehydratase (Dickeya dianthicola ME23)
MQSIIKIHSLDNVAVALRDLAQDEAVSVGDISLTLPQAVARGHKFALKPIAPGEMIVKYG
LPIGHALVAIAPGEHIHSQNAKTNLSDLDQYQYQPEFISLPAQVADRDVQVYRRKNGDVG
IRNELWILPTVGCVNGIARQILQRFLKETNDAEGIDGVYLFTHPFGCSQLGQDHENTRTM
LQNMVRHPNAGAVLVIGLGCENNQVSAFRDTLGEFDADRVNFMICQQQEDEVEAGLERLH
PLYQVMRDDKRVPGKLSELKFGLECGGSDGLSGITANPLLGRFSDYLIANGGTTVLTEVP
EMFGAERILMSRCRDEATFEKTVHMVNDFKQYFIEHNQPIYENPSPGNKAGGITTLEEKS
LGCTQKAGQSQVVDVLKYGERLHTPGLNLLSAPGNDAVATSALAGAGCHMVLFSTGRGTP
YGGFVPTVKLATNTELAQKKPHWIDFDAGRLIHGMSMDELLSQFVELIVEIANGKPAKNE
INDFRELAIFKSGVTL