Protein Info for DZA65_RS02835 in Dickeya dianthicola ME23

Annotation: protein-disulfide reductase DsbD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 578 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 180 to 207 (28 residues), see Phobius details amino acids 219 to 243 (25 residues), see Phobius details amino acids 255 to 277 (23 residues), see Phobius details amino acids 298 to 329 (32 residues), see Phobius details amino acids 341 to 364 (24 residues), see Phobius details amino acids 376 to 393 (18 residues), see Phobius details amino acids 399 to 418 (20 residues), see Phobius details amino acids 430 to 448 (19 residues), see Phobius details PF11412: DsbD_N" amino acids 38 to 149 (112 residues), 109.8 bits, see alignment E=2.7e-35 PF13386: DsbD_2" amino acids 182 to 370 (189 residues), 31.7 bits, see alignment E=4.5e-11 PF02683: DsbD" amino acids 183 to 387 (205 residues), 68.5 bits, see alignment E=2.4e-22 PF13899: Thioredoxin_7" amino acids 475 to 550 (76 residues), 31.7 bits, see alignment E=4.3e-11 PF13098: Thioredoxin_2" amino acids 480 to 573 (94 residues), 39.3 bits, see alignment E=2.2e-13

Best Hits

Swiss-Prot: 67% identical to DSBD_PECAS: Thiol:disulfide interchange protein DsbD (dsbD) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K04084, thiol:disulfide interchange protein DsbD [EC: 1.8.1.8] (inferred from 95% identity to ddd:Dda3937_02715)

MetaCyc: 65% identical to thiol-disulfide exchange protein DsbD (Escherichia coli K-12 substr. MG1655)
RXN-19949 [EC: 1.8.4.16]; 1.8.4.16 [EC: 1.8.4.16]; 1.8.4.16 [EC: 1.8.4.16]; RXN0-7311 [EC: 1.8.4.16]

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.8

Use Curated BLAST to search for 1.8.1.8 or 1.8.4.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XV05 at UniProt or InterPro

Protein Sequence (578 amino acids)

>DZA65_RS02835 protein-disulfide reductase DsbD (Dickeya dianthicola ME23)
MAQRIFTLTRIFTLTTLCLSLFFSTLAPAQNPFGRSPQSQFLPVDQAFAFDFQQRGDRLT
LSWQIHPGYYLYRQQIKLDNTLIAPPGLTLPPGELHRDEFFGEVAIYRQSLTLNVPLRDV
PPGASLSITYQGCADAGFCYPPETRSVPLSAITNDTTATPAAATPQPDRAYTPQLPFSPL
WALLIGIGVAFTPCVLPMYPLISGLILGRQQRLSTGRTLLLTLVYVQGMALTYTLLGLVV
AAAGLRFQAALQHPYVLIGLSVMFVALALSMFGVYSLQLPSSLQTRLTLWSNRQQSGSAV
GVFAMGALAGLICSPCTTAPLSALLLYIAQSGNLLAGGGSLYLYALGMGLPLMAITLFGS
RLLPKRGPWMTHVKEGFGFVILALPVFLLGRVLGDTWEWRLWGLLGVAFFGWAFALSLRS
HAGGMRAVQVLLFLGALLAARPLQDWVFAPVQAEPTSSSQLHFTPTNTLDDLTTALGRSD
NRITMLDLYADWCVACKEFEKYTFRDAAVQQSLSAMQRLQADVTANNETQRALLQHLQVL
GLPTILFFDASGREIPGSRVTGFMDAAAFAAHLQALAR