Protein Info for DZA65_RS01945 in Dickeya dianthicola ME23

Annotation: FAD-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 563 PF13454: NAD_binding_9" amino acids 47 to 89 (43 residues), 22.6 bits, see alignment 1.4e-08 PF13450: NAD_binding_8" amino acids 48 to 117 (70 residues), 35.5 bits, see alignment E=1.4e-12 PF01593: Amino_oxidase" amino acids 53 to 541 (489 residues), 309 bits, see alignment E=1.2e-95

Best Hits

Swiss-Prot: 72% identical to TR2M_PANAY: Tryptophan 2-monooxygenase (iaaM) from Pantoea agglomerans pv. gypsophilae

KEGG orthology group: K00466, tryptophan 2-monooxygenase [EC: 1.13.12.3] (inferred from 90% identity to dze:Dd1591_3740)

MetaCyc: 68% identical to tryptophan 2-monooxygenase (Pseudomonas savastanoi)
Tryptophan 2-monooxygenase. [EC: 1.13.12.3]

Predicted SEED Role

"Tryptophan 2-monooxygenase (EC 1.13.12.3)" in subsystem Aromatic amino acid degradation (EC 1.13.12.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.13.12.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XTA7 at UniProt or InterPro

Protein Sequence (563 amino acids)

>DZA65_RS01945 FAD-dependent oxidoreductase (Dickeya dianthicola ME23)
MSINAAFLVNSVPCVDLLYDYAPFLQRSEAEGRIGYFPPGISTPRVAIVGAGISGLVAAT
ELLRAGVNDITLFEARDSRIGGRVWSQMFDPCYPHIIAEMGAMRFPSSESCLFYYLDKLG
IATTTSFPDPGVVDTELHYRGVRHIWSAGDPPPSLFSRVHEGWLALLNEGYLHNGVLLAA
PKDITAMLKSHCFDKARKAWQAWLDAFRDCSFYSALVVMFTSNTPPGGVPWRRPDDFELF
GSLGIGSGGFLPVYQAGFTEILRLVINGYEEDQRLIIGGISTLTERLAGQYIDNTCLSEH
ICFSEIRQIYKENDDIKLVSGRGQTYTFDRVIVTSCTRTMQIVHGLTGDETFLEHDTARA
VKETHLTGSSKLFMLTQNKFWLKHSLPVTIQSDGFIRGVYCLDYEPDNPDGPGVILLSYT
WEDDAHKLLSIPDKKQRCQHLVDDLANIHPEFARHLVPADGDYERYVLHHDWLVDPYSAG
AFKLNYPGEDVYSQRLFFQFKNANTPEKDTGLYLAGCGCSFTGGWIEGAIQTALNSACAV
IRSTGGTLLPGNPLDAMHSVYCY