Protein Info for DZA65_RS01645 in Dickeya dianthicola ME23

Annotation: aerobic respiration two-component sensor histidine kinase ArcB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 779 transmembrane" amino acids 20 to 46 (27 residues), see Phobius details amino acids 58 to 77 (20 residues), see Phobius details PF18415: HKR_ArcB_TM" amino acids 15 to 89 (75 residues), 101.8 bits, see alignment E=1e-32 TIGR00229: PAS domain S-box protein" amino acids 152 to 276 (125 residues), 56.9 bits, see alignment E=1.2e-19 PF00989: PAS" amino acids 156 to 266 (111 residues), 63.6 bits, see alignment E=5.8e-21 PF08448: PAS_4" amino acids 161 to 271 (111 residues), 63 bits, see alignment E=1e-20 PF00512: HisKA" amino acids 283 to 345 (63 residues), 61.4 bits, see alignment 2.4e-20 PF02518: HATPase_c" amino acids 395 to 503 (109 residues), 99 bits, see alignment E=7.8e-32 PF00072: Response_reg" amino acids 528 to 639 (112 residues), 79.7 bits, see alignment E=6.5e-26 PF01627: Hpt" amino acids 686 to 769 (84 residues), 54.4 bits, see alignment E=4.3e-18

Best Hits

Swiss-Prot: 74% identical to ARCB_ECOLI: Aerobic respiration control sensor protein ArcB (arcB) from Escherichia coli (strain K12)

KEGG orthology group: K07648, two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC: 2.7.13.3] (inferred from 96% identity to ddc:Dd586_0311)

MetaCyc: 74% identical to sensor histidine kinase ArcB (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

"Aerobic respiration control sensor protein arcB (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XSE3 at UniProt or InterPro

Protein Sequence (779 amino acids)

>DZA65_RS01645 aerobic respiration two-component sensor histidine kinase ArcB (Dickeya dianthicola ME23)
MRQIRLLAQYYVDLMVKLGLVRFSLLLASALVLLALVVQMAVTLLLSGKVENIDVVRSIF
FGLLITPWAVYFLSVVVEQLEESRQRLSRLVAKLEEMRQRDQELNEQLQGNIAQLNQEIS
DRIKAEDARLLMVSKLREEMARREQAQVELEQQSALLRSFLDASPDLVYYRNENKEFSGC
NRAMELLLGKSQKQLIGLTPKDVYPPDIAEKVMETDEKVFRHNVSLTYEQWLVYPDGRKA
CFELRKVPFYDRMGKRHGLMGFGRDITERKRYQDALENASREKTTFISTISHELRTPLNG
IVGLSRILLDTHLDAEQQKYLKTIHVSAITLGNIFNDIIEMDKQERRKVQLDNQPVDFVG
FVVDLENLGGLLAQPKGLKLEMELHQPLPKTIVTDGTRLRQILWNLLSNAVKFTREGRVV
VRVWHEQGDRLCFEVEDSGMGIPADELEKIFSMYYQVKDQHGGKPATGTGIGLAVSKRLA
QSMGGDIQVTSELGKGSCFALTVTAPVVNDDESDEDEQDELPLPALHVLLVEDIELNVVV
ARSVLEKLGSSVDVAMTGQAALDMFDPDEFDLVLLDIQLPDMTGLDVARRLRERYAGQSM
PPLVALTANVLKDKKEYLDAGMDDVLSKPLAVPALTAVIQQYWDHHTQLEPEAAAVDTGS
QQDRLLDIPMLEQYLSLVGPKLIHQSLAMFEQMMPGYLAILDSNMTARDQKGIAEEGHKI
KGAAGSVGLRHLQQVAQQIQTTTLPAWWDNVQEWIDELKHDWQQDVQALKDWVSEAEKK