Protein Info for DZA65_RS01000 in Dickeya dianthicola ME23
Annotation: 4-hydroxy-3-polyprenylbenzoate decarboxylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 91% identical to UBID_PECAS: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (ubiD) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
KEGG orthology group: K03182, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD [EC: 4.1.1.-] (inferred from 98% identity to dze:Dd1591_3906)MetaCyc: 86% identical to 3-octaprenyl-4-hydroxybenzoate decarboxylase (Escherichia coli K-12 substr. MG1655)
3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN [EC: 4.1.1.98]
Predicted SEED Role
"3-polyprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-)" in subsystem Ubiquinone Biosynthesis (EC 4.1.1.-)
MetaCyc Pathways
- superpathway of chorismate metabolism (54/59 steps found)
- superpathway of ubiquinol-8 biosynthesis (early decarboxylation) (12/12 steps found)
- ubiquinol-8 biosynthesis (early decarboxylation) (8/8 steps found)
- plastoquinol-9 biosynthesis II (1/5 steps found)
- ubiquinol-10 biosynthesis (early decarboxylation) (2/8 steps found)
- ubiquinol-7 biosynthesis (early decarboxylation) (2/8 steps found)
- ubiquinol-9 biosynthesis (early decarboxylation) (2/8 steps found)
KEGG Metabolic Maps
- 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation
- 1- and 2-Methylnaphthalene degradation
- 3-Chloroacrylic acid degradation
- Ascorbate and aldarate metabolism
- Benzoate degradation via hydroxylation
- Biphenyl degradation
- Fluorene degradation
- Phenylalanine metabolism
- Phenylpropanoid biosynthesis
- Purine metabolism
- Pyruvate metabolism
- Tryptophan metabolism
- Tyrosine metabolism
- Ubiquinone and menaquinone biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 4.1.1.-
Use Curated BLAST to search for 4.1.1.- or 4.1.1.98
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A3A4CH32 at UniProt or InterPro
Protein Sequence (495 amino acids)
>DZA65_RS01000 4-hydroxy-3-polyprenylbenzoate decarboxylase (Dickeya dianthicola ME23) MKYRDLREFLAQLEARGELKRIHQPIDPYLEMTEIADRTLRAEGPALLFENPKGYGMPVL CNLFGTPKRVALGMGQEEISALRDVGRLLAFLKEPEPPRGFRDLVDKLPKFRQVLNMPTK RLSNAPCQEQVWEGDEVDLGRIPIMHCWPGDVAPLVTWGLTVTRGPSKERQNLGIYRQQR IGRNKLIMRWLSHRGGALDFQEWRQQHPGERFPVAVALGADPATILGAVTPVPDTLSEYA FAGLLRGHKTEVVKCLSSDLDVPASAEIVLEGYIDPDETAPEGPYGDHTGYYNEVDHFPV FTVTHVTQRRDAIYHSTYTGRPPDEPAVLGVALNEVFVPLLQKQFPEIVDFYLPPEGCSY RLAVVTMKKQYAGHAKRVMMGVWSFLRQFMYTKFVIVCDDDIDARDWKDVIWAITTRMDP ARDTVLVENTPIDYLDFASPVSGLGSKMGLDATNKWPGETQREWGHPITKDPSVVARVDA MWDELAILNDSGKPR