Protein Info for DZA65_RS00505 in Dickeya dianthicola ME23

Annotation: type III PLP-dependent enzyme

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00278: Orn_DAP_Arg_deC
  • amino acids 44 to 394 (351 residues), 51.7 bits, E=1.3e-17
• PF02784: Orn_Arg_deC_N
  • amino acids 50 to 300 (251 residues), 162.1 bits, E=2.5e-51
• PF01168: Ala_racemase_N
  • amino acids 50 to 218 (169 residues), 24.7 bits, E=2.7e-09

Best Hits

KEGG orthology group: K01586, diaminopimelate decarboxylase [EC: 4.1.1.20] (inferred from 90% identity to ddd:Dda3937_03216)

Predicted SEED Role

"Diaminopimelate decarboxylase (EC 4.1.1.20)" in subsystem Lysine Biosynthesis DAP Pathway (EC 4.1.1.20)

MetaCyc Pathways

• aspartate superpathway (24/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• L-lysine biosynthesis III (6/7 steps found)
• L-lysine biosynthesis VI (6/7 steps found)
• L-lysine biosynthesis II (7/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.20

Use Curated BLAST to search for 4.1.1.20

Sequence Analysis Tools

See A0A385XRZ0 at UniProt or InterPro

Protein Sequence (447 amino acids)

>DZA65_RS00505 type III PLP-dependent enzyme (Dickeya dianthicola ME23)
MTDPTHPHVRTEAGSPFANGYIFANGYIEEVAVADIAGRIGTPFYVYSARQLRRQLQQLR
QQLPTGIAVYYSLKANPNLSVVRVLAEQGAGCEVCSPTELKTALAAGVSPQHILYVGPGK
SLPALKFAIDCGIRAIVVESVAELDNLNQLAAQANTVQTVALRINPDFSSAHARLVMSGK
PTQFGMTLDTLDTVLTSLHRWPSVSLRGFHIYLGTRILNAQTIADNTRNILQLALNLRDT
HQLTLDFVDVGGGFGVPYFPKEAPLDLPALGEAVASIVADFLRQTADTQIIIELGRYLVA
EAGLFVTRVNTLKTAGGKTFAVCDGGANCHSAAAGLNSMLRKNFPLLRLGDNVDRPLQPY
QVSGPLCTPTDLLGDNVLLPMLAVDDLIGIPHSGAYGLTASPGSFLSFGYPPEVMVDGRR
LTLIRQPETTEQLLARQQPVDLSGDTP