Protein Info for DZA65_RS00230 in Dickeya dianthicola ME23

Annotation: urea carboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1197 PF00289: Biotin_carb_N" amino acids 1 to 110 (110 residues), 141.1 bits, see alignment E=8.5e-45 TIGR02712: urea carboxylase" amino acids 2 to 1193 (1192 residues), 1787.5 bits, see alignment E=0 PF02786: CPSase_L_D2" amino acids 116 to 318 (203 residues), 213.4 bits, see alignment E=1.2e-66 PF07478: Dala_Dala_lig_C" amino acids 143 to 291 (149 residues), 45 bits, see alignment E=4.1e-15 PF02785: Biotin_carb_C" amino acids 336 to 444 (109 residues), 97.1 bits, see alignment E=3e-31 TIGR00724: biotin-dependent carboxylase uncharacterized domain" amino acids 454 to 767 (314 residues), 312.4 bits, see alignment E=2.9e-97 PF02626: CT_A_B" amino acids 477 to 747 (271 residues), 310.7 bits, see alignment E=4.5e-96 PF02682: CT_C_D" amino acids 798 to 1019 (222 residues), 145 bits, see alignment E=1.1e-45 PF00364: Biotin_lipoyl" amino acids 1132 to 1192 (61 residues), 65.3 bits, see alignment 1.6e-21

Best Hits

KEGG orthology group: K01941, urea carboxylase [EC: 6.3.4.6] (inferred from 63% identity to abo:ABO_1892)

Predicted SEED Role

"Urea carboxylase (EC 6.3.4.6)" in subsystem Urea decomposition (EC 6.3.4.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4D948 at UniProt or InterPro

Protein Sequence (1197 amino acids)

>DZA65_RS00230 urea carboxylase (Dickeya dianthicola ME23)
MFERVLIANRGAIAVRIIRTLKKMGVKAIVVYAEADRHSLHVRQADEAWSLGDGPVRDTY
LNQDKLLHIAAESGAQAIHPGYGFLSENAGFVTRCEQAGLIFLGPTVAQMTAFGLKHQAR
ALAQQNAVPLLPGSGLLTSLDSACEQARRIGYPVMLKSTAGGGGIGMQRCNDQDQLVDAF
TRVKRLAGNNFADDGVFLEKFIARARHIEVQVFGDGQGNVIALGERDCSAQRRNQKVIEE
TPAPNLGDDVRAELQATAIRLCQAVNYRSAGTVEYVYDDSSKQFWFLEVNTRLQVEHGVT
EMVYGVDIVQWMVTLGAGCLPPLHTLAATPRGHAIQVRLYAEDPAKQFQPCAGLLSNVSF
PDSLPGLTLRIDHWLDSGCEVSPFYDPMLAKVLVHGDDRGAALDGMAQALNATSLYGIET
NLDWLRHLLTLPAVRRGEIITATLGSVVWQPATLDVLGGGTLTTVQDAPGRTGYWHVGVP
PSGPFDARSFRLGNQLLGNAPDAAGLEITLRGPTLRFNHDCAFIITGAVTDARLDDAPLT
GWRAHHARAGQTLTLGDIQAAGCRSYLLLAGGLACPMYLGSRSTFTLGKFGGHAGRALRA
GDVLHLAAPALPVADAAVPAPDWITHWSLRVIYGPHGAPDYFTPQDIDIFFAADWQVHYN
SSRTGIRLIGPKPQWARTDGGEAGMHPSNIHDNAYAFGTVDFTGDMPVILGPDGPSLGGF
VCPATVIHADLWKLGQLKAGDSIRFVPITLEQADELAREAEHAISAARPVEEQTLAACCP
PPVLYRRPAQDCRPSVTCLAAGDRFLLLEYGEHRLDIALRFRVHALMQWLEQHPLPGVQE
LTPGIRSLQIHFDSLQCPRSVLLAHLQHADDALGNLQDAAVPSRTVWLPLSWDDAACREA
ITRYTQSVRPGAPWCPSNIEFIRRINGLASVDQVKDIVFSARYLVMGLGDVYLGAPVATP
LDPRHRLVTTKYNPARTWTAENSVGIGGAYLCVYGMEGPGGYQFIGRTLQMWNRDRQTDA
FRQPWLLRFFDQIRFYPVTAQELLAARERFPWGDYPLRSEEGEFRLADYQRSLVEQQPAI
GAFQQQRQQAFDEELARWRADGQFTFDSSLQETVTDDEVIPPHGYGVESQVAGSVWQWLV
APGDTVSAGQVVGILESMKMEIPITAPVAGIIHTLHRQPGHQVQAGQLLMVIEPSGA