Protein Info for DDA3937_RS23255 in Dickeya dadantii 3937

Annotation: aminodeoxychorismate lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 54% identical to PABC_ECOLI: Aminodeoxychorismate lyase (pabC) from Escherichia coli (strain K12)

KEGG orthology group: K02619, 4-amino-4-deoxychorismate lyase [EC: 4.1.3.38] (inferred from 100% identity to ddd:Dda3937_02247)

MetaCyc: 54% identical to aminodeoxychorismate lyase (Escherichia coli K-12 substr. MG1655)
Aminodeoxychorismate lyase. [EC: 4.1.3.38]

Predicted SEED Role

"Aminodeoxychorismate lyase (EC 4.1.3.38)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Folate Biosynthesis (EC 4.1.3.38)

MetaCyc Pathways

superpathway of chorismate metabolism (54/59 steps found)
superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
4-aminobenzoate biosynthesis I (2/2 steps found)
4-aminobenzoate biosynthesis II (1/2 steps found)
superpathway of candicidin biosynthesis (4/11 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.3.38

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SHP7 at UniProt or InterPro

Protein Sequence (267 amino acids)

>DDA3937_RS23255 aminodeoxychorismate lyase (Dickeya dadantii 3937)
MWWIDGKAEQYLPVSDRSIQFGDGCFTTSRVVNGRIVWLDRHIRRLQQAAEKLLLPDPGW
QQLSDEMQQAAEGRVDGVVKAIISRGNGGRGYSPAGCDKPVRIVMQAAYPQHYVQWRQDG
IRLALSPVSLAQSAWLAGIKHLNRLEQVFIRMHLEQSGADEALVLDTSGALVECCAANLF
WRKGKRVFTPDVSLAGVDGVARRHIMALLSASAYELHVVTEPLETLADADEVLVCNALMP
VIPVNQAHIWCYRSRELYDCLSPNCES