Protein Info for DDA3937_RS20790 in Dickeya dadantii 3937

Annotation: acyl-CoA/acyl-ACP dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02770: Acyl-CoA_dh_M
  • amino acids 124 to 212 (89 residues), 51.9 bits, E=6.8e-18
• PF00441: Acyl-CoA_dh_1
  • amino acids 230 to 362 (133 residues), 36.4 bits, E=5.7e-13

Best Hits

KEGG orthology group: None (inferred from 100% identity to ddd:Dda3937_00957)

Predicted SEED Role

"Butyryl-CoA dehydrogenase (EC 1.3.99.2)" in subsystem Acetyl-CoA fermentation to Butyrate or Anaerobic respiratory reductases or Butanol Biosynthesis or Isobutyryl-CoA to Propionyl-CoA Module or Isoleucine degradation or Valine degradation (EC 1.3.99.2)

MetaCyc Pathways

• pyruvate fermentation to butanol II (engineered) (5/6 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (20/27 steps found)
• pyruvate fermentation to hexanol (engineered) (8/11 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Fatty acid metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.2

Use Curated BLAST to search for 1.3.99.2

Sequence Analysis Tools

See E0SMG0 at UniProt or InterPro

Protein Sequence (378 amino acids)

>DDA3937_RS20790 acyl-CoA/acyl-ACP dehydrogenase (Dickeya dadantii 3937)
MKALTFSNVLKELDALGEKLRQAASQVESDRSRALSCLEDELLYTIAYIGIPPEFIPFRG
WDYQACHYSDHIDMLEYLSRFDASGLMMLPGASLSARAVTMLGTPEQQAFFFSRFNQPPC
WAFFAVTEPEVGSDTQSIASSLTPTDNGYVLHARKKFIGGAQLASVGLVFAREGNLQRLV
MVEPEQAASHMTITPLEQFGLQGSNLTEIEINGLPVTPDRILGYHRKGLNQGLIALGQVF
ERHRPMVSAMALGTAYGLLRVLDDTALNAEQQRWRAQQWRTYHLLRRQLSETAARYQSGQ
PQYHITSQLKRRCTLFVETVAHRMPHLLGEQTWLEDAPLRRRCRDALAFEYMEGTANIHL
MNSFRCYTAKGGVCAHVS