Protein Info for DDA3937_RS20385 in Dickeya dadantii 3937

Annotation: HTH-type transcriptional regulator MetR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 312 PF00126: HTH_1" amino acids 4 to 63 (60 residues), 65.7 bits, see alignment E=3e-22 PF03466: LysR_substrate" amino acids 86 to 289 (204 residues), 156.8 bits, see alignment E=5e-50

Best Hits

Swiss-Prot: 90% identical to METR_ECO57: HTH-type transcriptional regulator MetR (metR) from Escherichia coli O157:H7

KEGG orthology group: K03576, LysR family transcriptional regulator, regulator for metE and metH (inferred from 100% identity to ddd:Dda3937_02052)

Predicted SEED Role

"Transcriptional activator MetR" in subsystem Methionine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SLJ3 at UniProt or InterPro

Protein Sequence (312 amino acids)

>DDA3937_RS20385 HTH-type transcriptional regulator MetR (Dickeya dadantii 3937)
MIELKHLRTLQALRNTGSLAAAAAQLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTP
QGEILLQLAEQILPQIQQALQACNEPHQTTLRLAIECHSCIQWLTPALENFHQSWPQVVM
DFKSGVTFDPQPALQQGELDLVMTSDILPRSGLHYSPMFDFEVRLVLSPDHPLAAKAVIT
PDDLAQETLMIYPVQRQRLDVWRHFLQPAGVSPSLKSVDNTLLLIQMVAARMGIAALPHW
VVESFERQGLVVTKTLGDGLWSRLYAAVRDGEQRQPVIEAFIRSARQHACEHLPFVRDAS
RPNTGAPTRPQQ