Protein Info for DDA3937_RS19915 in Dickeya dadantii 3937

Annotation: class I adenylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 852 PF12633: Adenyl_cycl_N" amino acids 5 to 200 (196 residues), 271 bits, see alignment E=7.4e-85 PF01295: Adenylate_cycl" amino acids 228 to 825 (598 residues), 862.7 bits, see alignment E=1.6e-263

Best Hits

Swiss-Prot: 99% identical to CYAA_DICCH: Adenylate cyclase (cya) from Dickeya chrysanthemi

KEGG orthology group: K05851, adenylate cyclase, class 1 [EC: 4.6.1.1] (inferred from 100% identity to ddd:Dda3937_00294)

MetaCyc: 83% identical to adenylate cyclase (Escherichia coli K-12 substr. MG1655)
Adenylate cyclase. [EC: 4.6.1.1]

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SKN1 at UniProt or InterPro

Protein Sequence (852 amino acids)

>DDA3937_RS19915 class I adenylate cyclase (Dickeya dadantii 3937)
MYFYIETLKQRLDAINQLRVDRALEAMKPAFQQVYSLLPVLLHHHHPLMPGYLEGKVPHG
ICLFSPDEKQQHYLDSVELRWGELSAPDRKGELPITGVYSMGSTSSIGQSCSSDLDIWVC
HQSWLDNEERQRLQQKCSLLEKWAAGQGVDVSFFLMDENRFRHNESGSLGGEDCGSTQHI
LLLDEFYRTAVRMAGKRILWNMVPVEEEAHYDEFVLSLYARGALAPNEWLDLGGLSALSA
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNTRLLSSEIKARLHKGEIVSFGLD
PYCMMLERVTQYLNAVNDQTRLDLVRRCFYLKVCEKLSRERACTAWRRQILTQMVQAWGW
SDERLVMLDNRANWKIGQVREAHNELLDAMMQSYRNLIRFARRNNLSVSASPQDIGVLTR
KLYAAFEALPGKVTLVNPQISPDLSETNLTFIYVPAGRANRSGWYLYNQAPSMDAIISHQ
PLEYNRYLNKLVAWAYFNGLLTSSTRLHIKGHELCDIARLQELVSDVSSHFPLRVAAPTP
KALYSPCEIRHLAIIVNLEHDPTAAFRNQVVHFDFRQLDVFSFGQQQQCLVGSIDLLYRN
SWNEVRTLHFSGEQAMLEALKTILGKMHQDAALPESLEVFCYSQHLRGLIRTRVQQLVSE
CIELRLSSTRQEPGRFKAVKVAGETWGLFFERLSVSAQKLENAVEFYGAISNNKLQGLPV
QVETNHIHLPPVVDGVASEGIIQFFFEDQHDNQGFNIYILDESNRVEVYHHCEGSKEELV
RDVSRFYSSSHDRFTYGSSFINFNLPQFYQIVQLDGRTQVIPFRSSALSHLCVTPSSEDK
KNLVLSQRLQML