Protein Info for DDA3937_RS19780 in Dickeya dadantii 3937

Annotation: gluconokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 172 PF01583: APS_kinase" amino acids 3 to 115 (113 residues), 21.6 bits, see alignment E=3.7e-08 TIGR01313: carbohydrate kinase, thermoresistant glucokinase family" amino acids 6 to 165 (160 residues), 222.3 bits, see alignment E=1.5e-70 PF13671: AAA_33" amino acids 6 to 137 (132 residues), 39.7 bits, see alignment E=1.2e-13 PF13238: AAA_18" amino acids 6 to 120 (115 residues), 31.5 bits, see alignment E=4.8e-11 PF01202: SKI" amino acids 13 to 160 (148 residues), 42.9 bits, see alignment E=1.2e-14

Best Hits

Swiss-Prot: 61% identical to IDNK_ECOLI: Thermosensitive gluconokinase (idnK) from Escherichia coli (strain K12)

KEGG orthology group: K00851, gluconokinase [EC: 2.7.1.12] (inferred from 100% identity to ddd:Dda3937_00323)

MetaCyc: 61% identical to D-gluconate kinase, thermosensitive (Escherichia coli K-12 substr. MG1655)
Gluconokinase. [EC: 2.7.1.12]

Predicted SEED Role

"Gluconokinase (EC 2.7.1.12)" in subsystem D-gluconate and ketogluconates metabolism or Entner-Doudoroff Pathway (EC 2.7.1.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SJW5 at UniProt or InterPro

Protein Sequence (172 amino acids)

>DDA3937_RS19780 gluconokinase (Dickeya dadantii 3937)
MSGQSIILMGVSGSGKSSVGARLAREINAKFIDGDDLHPRANIQKMASGQPLNDDDRAPW
LERLNDAAYSLLHKNETGIIVCSALKKRYRDRLREGNDGMVFLYLKGSFEVILQRHQARA
GHFMPTGLLQSQFDALEEPDETETDIITVDINGPMDQVVERCAAALRAHPSR