Protein Info for DDA3937_RS19490 in Dickeya dadantii 3937

Annotation: glutamate decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00282: Pyridoxal_deC
  • amino acids 79 to 367 (289 residues), 51.7 bits, E=2.9e-18

Best Hits

KEGG orthology group: K01590, histidine decarboxylase [EC: 4.1.1.22] (inferred from 100% identity to ddd:Dda3937_00519)

Predicted SEED Role

"Histidine decarboxylase (EC 4.1.1.22) (HDC) (TOM92)" (EC 4.1.1.22)

MetaCyc Pathways

• histamine biosynthesis (1/1 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Histidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.22

Sequence Analysis Tools

See E0SJQ5 at UniProt or InterPro

Protein Sequence (456 amino acids)

>DDA3937_RS19490 glutamate decarboxylase (Dickeya dadantii 3937)
MQPIDELTILAEGVHDVVRRRILRAYTARMEEQRRHFAGFQTNQQGEFDAVLRPLLDMNL
LNLGDSMEPGAYQVNSKRFERAVLDYYARLWNLPSPYWGYLTAMGSTEGNLFALWNARDF
LCGASTTHWPAMTRARYAPVVLYSERSHYSLAKACRVLQLATPAEAGPQLGRCPINAGVW
PRAVPCDDAGRIDVESLLQLVMFFHRYRRPVIVCLTSGTTFSGSCDDWSLITARLRQLLP
PNTPQQRSYWVHVDGALSSSYLPFWPEPEGRRLAIDAQAASLHSICASPYKWLSMPWPCG
VVMLSEPYRAVALSRPNYIGSGDATLSGSRPGLSAVVLWNQLCRLGEPGQREMIRRCHEI
QRYAHQQFRYLFERLDPGRERLLLQPLISGSLMVQFSAPSPSVIERFSLSSEQLMVQGKS
VLFCHLVVLPHCHRALVDNLLWALGQPGAFPSVGEV