Protein Info for DDA3937_RS19345 in Dickeya dadantii 3937

Annotation: phosphoethanolamine transferase EptA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 547 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 50 to 72 (23 residues), see Phobius details amino acids 79 to 101 (23 residues), see Phobius details amino acids 125 to 143 (19 residues), see Phobius details amino acids 155 to 177 (23 residues), see Phobius details PF08019: EptA_B_N" amino acids 59 to 210 (152 residues), 155.3 bits, see alignment E=1.1e-49 PF00884: Sulfatase" amino acids 238 to 528 (291 residues), 238.7 bits, see alignment E=9.3e-75

Best Hits

Swiss-Prot: 60% identical to EPTA_ECOLI: Phosphoethanolamine transferase EptA (eptA) from Escherichia coli (strain K12)

KEGG orthology group: K03760, phosphoethanolamine transferase (inferred from 100% identity to ddd:Dda3937_00525)

MetaCyc: 60% identical to phosphoethanolamine transferase EptA (Escherichia coli K-12 substr. MG1655)
RXN-14379 [EC: 2.7.8.43]

Predicted SEED Role

"Phosphoethanolamine transferase EptA specific for the 1 phosphate group of core-lipid A" in subsystem Lipid A modifications

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.43

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SIY3 at UniProt or InterPro

Protein Sequence (547 amino acids)

>DDA3937_RS19345 phosphoethanolamine transferase EptA (Dickeya dadantii 3937)
MFKMSRLSRPVWSSFTYNLVFAAFITLIQNIAYYRQVSHLVAINTWRDGLFLATMPVVIF
AVLNVLFALLFISWLRQGVVALLLVGGAAVQYFMINYGIIIDRTMMQNVFETNMAESMAL
VTPQYLLWLTLLGIVPALGALWVKIKPTPLSWVTIGARCFSILMSIVAILLVATFFYKDY
ASLMRNNKELVKSLTPSNIIFANISYYRHRAQANLPLVQIGLDAHKKPLASGDAKKNLVI
LVVGETSRAENFSLGGYDKPTNPRLANDNVLYFSQTASCGTSTGVSVPCMFSNMPRAGYD
EQLAAHQEGLLDVLQHAGVNVRWQENDGGCKGACDRVPSTDITALNLPDQCSGGECHDEA
LFSGVEDYINQLNNDGIIVLHTMGSHGPAYYQRYPDDFRKFTPTCDTNQIQTCSRESLIN
TYDNTILYVDYIVDKAINVLKGHQDKFNTALVYLSDHGESLGEDGIYLHSMPYAVAPTQQ
THIPMLMWLSGGYQQQFSIDDSCMRKQAGQQRFSQDNLFHTVLGMFNIATKEYQAPLDIL
QPCRGTS