Protein Info for DDA3937_RS18585 in Dickeya dadantii 3937
Annotation: adenylosuccinate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 93% identical to PURA_PECCP: Adenylosuccinate synthetase (purA) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)
KEGG orthology group: K01939, adenylosuccinate synthase [EC: 6.3.4.4] (inferred from 100% identity to ddd:Dda3937_00429)MetaCyc: 87% identical to adenylosuccinate synthetase (Escherichia coli K-12 substr. MG1655)
Adenylosuccinate synthase. [EC: 6.3.4.4]
Predicted SEED Role
"Adenylosuccinate synthetase (EC 6.3.4.4)" in subsystem CBSS-262719.3.peg.410 or Purine conversions (EC 6.3.4.4)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (26/26 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
- superpathway of purine nucleotide salvage (13/14 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis II (7/7 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
- adenosine ribonucleotides de novo biosynthesis (3/3 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Biosynthesis of alkaloids derived from histidine and purine
- Purine metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 6.3.4.4
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See E0SH66 at UniProt or InterPro
Protein Sequence (432 amino acids)
>DDA3937_RS18585 adenylosuccinate synthase (Dickeya dadantii 3937) MGKNVVVLGTQWGDEGKGKVVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGI LRENVISIIGNGVVLAPDALLKEMTALEARGVPVRERMLLSEACPLILPYHVALDNAREK ARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDRESFAVKLKEIMDYHNFQLVHYYKTD PVDYQKTLNDVLEVADILTAMVVDVSDLLHKAHQRGDRVMFEGAQGTLLDIDHGTYPYVT SSNTTAGGVATGSGLGPRYVDYVLGIVKAYSTRVGAGPFPTELFDDVGEHLSQKGNEFGA TTGRRRRTGWLDAVAVRRAVQINSLSGFCLTKLDVLDGLKEVKICVGYRMPNGSEVDVTP LAAEGWEGIEPIYETLPGWSESTFGVKEYSKLPQAALNYIKRIEEVTGVPVDIISTGPDR EETMVLRDPFDA