Protein Info for DDA3937_RS18535 in Dickeya dadantii 3937

Annotation: biosynthetic arginine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01273: arginine decarboxylase
  • amino acids 32 to 656 (625 residues), 896.2 bits, E=5.9e-274
• PF02784: Orn_Arg_deC_N
  • amino acids 101 to 367 (267 residues), 198.4 bits, E=2e-62
• PF17810: Arg_decarb_HB
  • amino acids 391 to 478 (88 residues), 99.4 bits, E=1.7e-32
• PF17944: Arg_decarbox_C
  • amino acids 606 to 655 (50 residues), 60.1 bits, 3.4e-20

Best Hits

Swiss-Prot: 88% identical to SPEA_YERPE: Biosynthetic arginine decarboxylase (speA) from Yersinia pestis

KEGG orthology group: K01585, arginine decarboxylase [EC: 4.1.1.19] (inferred from 100% identity to ddd:Dda3937_00418)

MetaCyc: 86% identical to biosynthetic arginine decarboxylase (Escherichia coli K-12 substr. MG1655)
Arginine decarboxylase. [EC: 4.1.1.19]

Predicted SEED Role

"Biosynthetic arginine decarboxylase (EC 4.1.1.19)" in subsystem Acid resistance mechanisms or Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.19)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (14/17 steps found)
• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (3/3 steps found)
• putrescine biosynthesis II (3/3 steps found)
• arginine dependent acid resistance (1/1 steps found)
• superpathway of polyamine biosynthesis II (6/8 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (1/2 steps found)
• putrescine biosynthesis I (1/2 steps found)
• superpathway of polyamine biosynthesis I (5/8 steps found)
• spermidine biosynthesis III (2/4 steps found)
• superpathway of putrescine biosynthesis (2/4 steps found)
• superpathway of L-arginine and L-ornithine degradation (6/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (4/11 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.19

Sequence Analysis Tools

See E0SH55 at UniProt or InterPro

Protein Sequence (658 amino acids)

>DDA3937_RS18535 biosynthetic arginine decarboxylase (Dickeya dadantii 3937)
MSDDMIQPYSSAAGKHDHLRSMQEVAMNDRDASEMLRTYNIAWWGNNYYDVNELGHISVC
PDPDVPEARVDLAKLVKTRQQNNQRLPALFCFPQILQHRLRSINAAFKRARESFGYEGGY
FLVYPIKVNQHRRVIESLINSGEPLGLEAGSKAELMAVLGHAGMTRSVIVCNGYKDREYI
RLALIGEKLGHKVYLVIEKMSEINMVLEEAERLNVVPRLGVRARLASQGSGKWQSSGGEK
SKFGLAATQVLQLVELLRKANRLDSLQLLHFHLGSQLANIRDIATGVRESARFYVELHKL
GVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNVIWGIGDACNEYGLPHPTVITE
SGRAVTAHHTVLVSNIIGVERNEFSEPVAPDEDAPRALESLWNTWQEIKEPGNRRSLREW
LHDSQMDLHDIHTQYTHGMLDLTQRAQAEQLYLNICQQIQQQLDPSNRAHRPIIDELQER
MADKLYVNFSLFQSMPDAWGIDQLFPVLPLEGLDKPPQRRAVLLDITCDSDGAIDHYVDG
DGVATTMPMPPYDPENPPLLGFFMVGAYQEILGNMHNLFGDTSTVDVFVFQDGTVELEES
DEGNTVADMLEYVQLDPDVLMSRFRDQVKETDLAPELQAQFLEEFETGLYGYTYLEDE