Protein Info for DDA3937_RS18140 in Dickeya dadantii 3937
Annotation: tryptophanase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 90% identical to TNAA_YERE8: Tryptophanase (tnaA) from Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
KEGG orthology group: K01667, tryptophanase [EC: 4.1.99.1] (inferred from 100% identity to ddd:Dda3937_01355)MetaCyc: 85% identical to tryptophanase subunit (Klebsiella aerogenes)
Tryptophanase. [EC: 4.1.99.1]
Predicted SEED Role
"Tryptophanase (EC 4.1.99.1)" in subsystem Aromatic amino acid degradation (EC 4.1.99.1)
MetaCyc Pathways
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- D-serine degradation (3/3 steps found)
- L-serine degradation (3/3 steps found)
- L-tryptophan degradation II (via pyruvate) (3/3 steps found)
- L-methionine biosynthesis II (5/6 steps found)
- L-cysteine degradation II (2/3 steps found)
- glycine betaine degradation III (4/7 steps found)
- felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis (2/5 steps found)
- L-mimosine degradation (4/8 steps found)
- glycine betaine degradation I (4/8 steps found)
- glutathione-mediated detoxification I (3/8 steps found)
- purine nucleobases degradation II (anaerobic) (13/24 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.99.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See E0SG98 at UniProt or InterPro
Protein Sequence (466 amino acids)
>DDA3937_RS18140 tryptophanase (Dickeya dadantii 3937) MKRIPEPFRIKMVENIRMTTRDERERALQEAGYNPFLLRSEDVYIDLLTDSGTGAMSDRQ WAGLMMGDEAYAGSRNYYHLCDQVKSLLGYPFTIPTHQGRGAEQILFPCLIAKKQRAGGG KKPVFISNFHFDTTAAHVELNGARAINVVTPKAFDTTAYYDWKGDFDLDLLHTTIEQHGA DNVVAIITTVTCNSSGGQPISMGNMREVYRIAQQHGIPVVIDSARFCENAWFIKQREAGY ENRSIKEIVHEMYQYGDMLTMSAKKDPMVNIGGLCCFRSDEELFNEVRIRCVPMEGFVTY GGLAGRDMEALAIGLEEGMNEDYLTYRIGQVTYLGERLRAGGIPIQYPVGGHAVFVDAKK LLPHIPAEQFPAQALNNELYLEAGIRSVEIGSLLLGRDPDTGEQKPSPLELLRLTIPRRV YTNDHMDYIADSLIALKERASGIKGLTFTYEPPVLRHFVARLKPVE