Protein Info for DDA3937_RS15865 in Dickeya dadantii 3937

Annotation: dGTPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 505 TIGR01353: putative dGTPase" amino acids 30 to 503 (474 residues), 409.9 bits, see alignment E=8.2e-127 PF01966: HD" amino acids 66 to 133 (68 residues), 31.1 bits, see alignment E=2.5e-11 PF13286: HD_assoc" amino acids 464 to 500 (37 residues), 27.9 bits, see alignment 2.9e-10

Best Hits

Swiss-Prot: 67% identical to DGTP_YERPY: Deoxyguanosinetriphosphate triphosphohydrolase (dgt) from Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

KEGG orthology group: K01129, dGTPase [EC: 3.1.5.1] (inferred from 100% identity to ddd:Dda3937_00497)

MetaCyc: 62% identical to dGTP triphosphohydrolase (Escherichia coli K-12 substr. MG1655)
dGTPase. [EC: 3.1.5.1]

Predicted SEED Role

"Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1)" in subsystem Purine conversions (EC 3.1.5.1)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.5.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SBJ5 at UniProt or InterPro

Protein Sequence (505 amino acids)

>DDA3937_RS15865 dGTPase (Dickeya dadantii 3937)
MSDIDFSKKISFQRPFSKPKDKKDAYAIEREFESDRGRIINSAAIRRLQQKTQVFPLERN
AAVRSRLTHSMEVQQVGRYIAKEILGQLRKSGQLGALGLGTLETPFESLIEMACLMHDIG
NPPFGHFGEAAINNWFSQRLAPEGKPPGAGEDPCQVACLRLDDEGEAELNALRSRIRHDL
SNFEGNAQAIRLVHSLLKLNLTYAQVGCILKYTKPAYWAQSIPHEYSYLMKKAGFYLSEE
TFVRQLRSELEMGEFHRHPLTYIMEAADDISYCIADLEDAVEKKIVTYQQLYERLEDAWG
TREEKDVFSRTIERAYTERQHMQGRSESDQFFMKLRVNTVNTMVGYVTRRFIEHLPAIYD
GSFNRSLLEEDKDDYGRLLKIFKDVARKFVFNHHEVEQLELQGDRIISGLLEIYSPLLNM
PYHDFCQLVNDDTHKRYPIETRLYHKLSSKHCHAYREATCALPALPAAEQEVWEYYYRAR
LILDYISGMTDLYAYDEYRRLMAVD