Protein Info for DDA3937_RS15280 in Dickeya dadantii 3937

Annotation: two-component system sensor histidine kinase BaeS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 transmembrane" amino acids 6 to 30 (25 residues), see Phobius details amino acids 157 to 176 (20 residues), see Phobius details PF00672: HAMP" amino acids 175 to 225 (51 residues), 51.8 bits, see alignment 1.2e-17 PF00512: HisKA" amino acids 231 to 292 (62 residues), 48.5 bits, see alignment E=1.1e-16 PF02518: HATPase_c" amino acids 339 to 450 (112 residues), 89 bits, see alignment E=4.3e-29

Best Hits

Swiss-Prot: 61% identical to BAES_ECOLI: Signal transduction histidine-protein kinase BaeS (baeS) from Escherichia coli (strain K12)

KEGG orthology group: K07642, two-component system, OmpR family, sensor histidine kinase BaeS [EC: 2.7.13.3] (inferred from 100% identity to ddd:Dda3937_02817)

MetaCyc: 61% identical to sensor histidine kinase BaeS (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

"Sensory histidine kinase BaeS"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SN37 at UniProt or InterPro

Protein Sequence (452 amino acids)

>DDA3937_RS15280 two-component system sensor histidine kinase BaeS (Dickeya dadantii 3937)
MKFGITARLFLAIFSTCMLVLVIMHFGVRLSFEKGFIDYIRRGNEQRVVQIRGWLEEQYQ
QYGNWDFLHNNERGIFPMLRAMEQNNDEAMQGWRTRFWVTDENRRRLIGPPIPMPAGSSW
QPLTVKKQTVGWLVAAPVEGLTRSADISFDHQQQRTSWLIVAFTTLLAAMVTWMMSRGLL
APVKRLVNGIHQLAGGDFGTRVSANGRDELGRLAQDFNQLASALEKNEQSRRAFMADISH
ELRTPLAVLRGELEALQDGVRRPDAAAFGSLQSEVALLTKLVDDLHQLSLSDLGALAYRK
AAVNASALLQVSVAAFRERFQQKGIRLTTRLHPEAIVFGDPDRLNQLFNNLMENSLRYTD
NEGQLEVETELRQQRLIIHWRDSAPGISDEQLALIFERFYRAESSRNRASGGSGLGLSIC
ANIVEAHDGRLYADHSALGGVQITVELPLHLS