Protein Info for DDA3937_RS14980 in Dickeya dadantii 3937
Annotation: mannitol dehydrogenase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 71% identical to YDFI_ECOLI: Uncharacterized oxidoreductase YdfI (ydfI) from Escherichia coli (strain K12)
KEGG orthology group: K00040, fructuronate reductase [EC: 1.1.1.57] (inferred from 100% identity to ddd:Dda3937_01658)MetaCyc: 59% identical to D-mannonate oxidoreductase (Escherichia coli K-12 substr. MG1655)
Fructuronate reductase. [EC: 1.1.1.57]
Predicted SEED Role
"D-mannonate oxidoreductase (EC 1.1.1.57)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 1.1.1.57)
MetaCyc Pathways
- superpathway of hexuronide and hexuronate degradation (9/10 steps found)
- D-fructuronate degradation (4/4 steps found)
- superpathway of β-D-glucuronosides degradation (6/7 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.57
Use Curated BLAST to search for 1.1.1.57
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See E0SM82 at UniProt or InterPro
Protein Sequence (490 amino acids)
>DDA3937_RS14980 mannitol dehydrogenase family protein (Dickeya dadantii 3937) MTLSHAALPHLPDAVITPAYDRAALKTRIVHLGFGAFHRAHQAVYADRLAAEHASDWGYC DINLIGGEQHIADLRRQDHLFSVAEMSPQAWHCRVVGVVRQALHAETDGIEAVLAAMSQP DIAIVSLTVTEKGYCHSPATGQLLLDHPLITADLAHPSAPRSAPGVIVAALARRKAAGLP AFSVMSCDNMPENGRVTRNVVLAYARALDPELAVWIEQHATFPSTMVDRIVPAVTADTLS QLAGQLGVDDPVGVACEPFAQWVIEDQFVNGRPAWEKVGVELVQDVLPYEEMKLRMLNGS HSFLAYLGYLAGYTHISDCMQDPALVAAARHLMMQEQAPTLRTRGVDLVAYADALLQRYR NTALKHRTWQIAMDGSQKLPQRMLDSIRWHLAHDSRFDMLALGVAGWMRYVGGVDEQGQP IEISDPLKEALALAVQHSEQGEARVRALLAQETIFGRDLPTDGRFVQTVTRYYLSLVNHG VKATLQALTQ