Protein Info for DDA3937_RS14960 in Dickeya dadantii 3937

Annotation: iron-containing alcohol dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00465: Fe-ADH
  • amino acids 8 to 345 (338 residues), 170.1 bits, E=6.6e-54
• PF13685: Fe-ADH_2
  • amino acids 15 to 276 (262 residues), 105 bits, E=5.9e-34

Best Hits

KEGG orthology group: K00005, glycerol dehydrogenase [EC: 1.1.1.6] (inferred from 89% identity to ddc:Dd586_2938)

MetaCyc: 33% identical to glycolaldehyde reductase (Halobacterium salinarum)
Lactaldehyde reductase. [EC: 1.1.1.77]

Predicted SEED Role

"Glycerol dehydrogenase (EC 1.1.1.6)" in subsystem Respiratory dehydrogenases 1 (EC 1.1.1.6)

MetaCyc Pathways

• superpathway of glycol metabolism and degradation (7/7 steps found)
• ethylene glycol degradation (2/2 steps found)
• glycerol degradation to butanol (12/16 steps found)
• L-lactaldehyde degradation (anaerobic) (1/1 steps found)
• glycerol degradation II (1/2 steps found)
• glycerol degradation V (1/2 steps found)
• superpathway of fucose and rhamnose degradation (7/12 steps found)
• methylglyoxal degradation VI (1/4 steps found)
• superpathway of glycerol degradation to 1,3-propanediol (1/4 steps found)
• nucleoside and nucleotide degradation (halobacteria) (2/6 steps found)

KEGG Metabolic Maps

• Glycerolipid metabolism
• Glyoxylate and dicarboxylate metabolism
• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.6, 1.1.1.77

Use Curated BLAST to search for 1.1.1.6 or 1.1.1.77

Protein Sequence (362 amino acids)

>DDA3937_RS14960 iron-containing alcohol dehydrogenase family protein (Dickeya dadantii 3937)
MTQQVFFPATVLRGAGVSQQLGEVCARLGSRVLVVGGHQALTAAQTLIIEQLRQAGVTLT
AVEWSGEQCSVSQIERLCARVRETGSDLLLAVGGGKALDTGKAVAFQCGIPVVTLPTIAA
TCAAVTPLSVRYHDDGHFHDLYHLPAAPAAVVIDSSLLVRAPLRWLAAGLGDTLAKWYEF
RAIDTGDNGSGFAASSRANGEICFRLIEQHGEAACRAVIDGQPSDALDQVLDAIFLFAGL
TSLMASGAHAAASHALYEGFTVCDKTREFGHGLLVGFGNLCLLALEQRSDEELLAAIRLA
QACAVPLTLAAICPDLSEAELTAIVRASVDAPDMANMPFTVTEQRVRQAIHRVETLATSV
AA