Protein Info for DDA3937_RS14480 in Dickeya dadantii 3937

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 463 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 168 to 190 (23 residues), see Phobius details PF08521: 2CSK_N" amino acids 19 to 165 (147 residues), 157 bits, see alignment E=6.2e-50 PF00672: HAMP" amino acids 189 to 239 (51 residues), 25 bits, see alignment 3.9e-09 PF00512: HisKA" amino acids 245 to 308 (64 residues), 37.2 bits, see alignment E=4.9e-13 PF02518: HATPase_c" amino acids 357 to 458 (102 residues), 63.3 bits, see alignment E=5.6e-21

Best Hits

KEGG orthology group: K07649, two-component system, OmpR family, sensor histidine kinase TctE [EC: 2.7.13.3] (inferred from 100% identity to ddd:Dda3937_02109)

Predicted SEED Role

"Tricarboxylate transport sensor protein TctE"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SL95 at UniProt or InterPro

Protein Sequence (463 amino acids)

>DDA3937_RS14480 sensor histidine kinase (Dickeya dadantii 3937)
MLKVNSLRGQLMLYLVVPMALLWALSVWSHYHSAKAAATQAYDRTLLASARTVAERLTVR
NGQLAVDVPWVVLDSFERNMNDRLYYQVLTPQGNTLSGYDDLPPLPRGMPLSRDYPALAH
FYDARYHGRAIRVAALWQPVHESGVEGMVLILVAETLSSREAFAHRQLLTAALSQSALVL
LALVLVLLLFRKLLRPLRQLSGVMARREPGDLTPLPPLLPWSEMQPLLVAFNRYIGRLSG
LVQRQERFGADAAHQLRTPLAVLKTQVGVALNSSQPAQWRDSLTGMSATLDSTIQLTDRL
LQLSRLRAQDSKEHTWQTVDLAELVHDVCFSRLPLARSRRIDLGYEGDERCLIRGEPLLL
AELCANLLDNALKYTPSGGIVTARVQAQQLDVEDSGPGIPPAEREQAMRPFHRLDNHGGL
PGAGLGLALVRDIARWHRTQVQLLDSPTLGGLRVRIVFGEPPA