Protein Info for DDA3937_RS14335 in Dickeya dadantii 3937

Annotation: NADH-quinone oxidoreductase subunit A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00507: Oxidored_q4
  • amino acids 27 to 123 (97 residues), 111.6 bits, E=9.2e-37

Best Hits

Swiss-Prot: 85% identical to NUOA_PECAS: NADH-quinone oxidoreductase subunit A (nuoA) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K00330, NADH dehydrogenase I subunit A [EC: 1.6.5.3] (inferred from 100% identity to ddd:Dda3937_04294)

MetaCyc: 83% identical to NADH:quinone oxidoreductase subunit A (Escherichia coli K-12 substr. MG1655)
NADH-DEHYDROG-A-RXN [EC: 7.1.1.2]; 7.1.1.- [EC: 7.1.1.2]

Predicted SEED Role

"NADH ubiquinone oxidoreductase chain A (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• aerobic respiration III (alternative oxidase pathway) (3/3 steps found)
• NADH to cytochrome bd oxidase electron transfer I (2/2 steps found)
• NADH to fumarate electron transfer (2/2 steps found)
• nitrate reduction VIII (dissimilatory) (2/2 steps found)
• NAD(P)/NADPH interconversion (4/6 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• NADH to dimethyl sulfoxide electron transfer (1/2 steps found)
• NADH to hydrogen peroxide electron transfer (1/2 steps found)
• NADH to trimethylamine N-oxide electron transfer (1/2 steps found)
• aerobic respiration I (cytochrome c) (2/4 steps found)
• Fe(II) oxidation (1/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3 or 7.1.1.2

Sequence Analysis Tools

See E0SKI4 at UniProt or InterPro

Protein Sequence (147 amino acids)

>DDA3937_RS14335 NADH-quinone oxidoreductase subunit A (Dickeya dadantii 3937)
MSTTTEVLAHHWAFALFVIVAVGLCGFMLLGGFLLGGRARARHKNIPYESGIDSVGSARL
RLSAKFYLVAMFFVIFDVEALYLYAWSVSIRESGWIGFVEATIFILVLLAGLIYLVRIGA
LDWTPSRSKRQVVKSNVVAQTPNTHQQ